Urinary PCA3 a Superior Diagnostic Biomarker for Prostate Cancer among Ghanaian Men

Table 6

Diagnostic performance of combination of diagnostic tools for prostate cancer.

Variable	Sensitivity (95% CI)	Specificity (95% CI)	PPV (%)	NPV (%)	TP	TN	FP	FN
PSA + DRE	100.0 (92.9-100)	2.9 (1.1–6.8)	27.2	100.0	63	5	169	0
PSA + PCA3 score	71.4 (59.2–81.1)	52.9 (45.5–60.1)	35.4	83.6	45	92	82	18
DRE+PCA3 score	60.3 (48.0–71.4)	80.5 (73.9–85.7)	52.8	84.8	38	140	34	25
PSA+DRE+PCA3 score	60.3 (48.0–71.4)	78.2 (71.4–83.7)	50.0	84.5	38	136	38	25

PSA: prostate-specific antigen; PCA3: prostate cancer antigen 3; DRE: digital rectal examination; CI: confidence interval; PPV: positive predictive value; NPV: negative predictive value; TP: true positive; TN: true negative; FP: false positive; FN: false negative.