LTB4 Promotes Acute Lung Injury via Upregulating the PLCε-1/TLR4/NF-κB Pathway in One-Lung Ventilation

Figure 3

Inhibiting LTB4 alleviates the OLV-induced ALI. (a, b) H&E staining examined the pathology of lung tissues in control, OLV, and bestatin-treated rats. (c) The lung W/D ratio of lung tissues in control, OLV, and bestatin-treated rats was calculated. (d) The PMN/WBC ratio of BALF in control, OLV, and bestatin-treated rats was detected. (e–k) ELISA performed to examine the levels of inflammation mediators (GM-CSF, IL-1β, IL-8, KC, MCP-1, MIP-2, and TNF-α) in control, OLV, and bestatin-treated rats. (l–o) Western blot detected the protein levels of Bcl-2, Bax, caspase 3, MLCK, VE-cadherin, occludin, and ZO-1 in control, OLV, and bestatin-treated rats. , , and .

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