Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis
Table 4
Association of different genotype of the the studied variants with disease subtypes.
Disease type
Case genotypes of TCF4 rs1261084C/T
Test of sig
Within-group comparison
Case genotypes of CACNA1C rs10774053A/G
Test of sig
Within-group comparison
CC
CT
TT
AA
AG
GG
BDI
41 (22.4)
82 (44.8)
60 (32.8)
: 0.384 : 0.825
: 0.585 : 0.561 : 0.938
36 (19.7)
85 (46.4)
62 (33.9)
: 2.83 : 0.242
: 0.093 : 0.275 : 0.560
BDII
13 (18.8)
32 (46.4)
24 (34.8)
20 (29.0)
26 (37.7)
23 (33.3)
Disease type
Case genotypes of CACNA1C rs10466907G/T
Test of sig
Within-group comparison
Case genotypes of miR-137 rs1625579A/C
Test of sig
Within-group comparison
GG
GT
TT
AA
AC
CC
BDI
57 (31.1)
90 (49.2)
36 (19.7)
: 6.68 : 0.036
: 0.014 : 0.425 : 0.184
65 (35.5)
82 (44.8)
36 (19.7)
: 2.46 : 0.292
: 0.668 : 0.226 : 0.117
BDII
12 (17.4)
46 (66.7)
11 (15.9)
25 (36.2)
36 (52.2)
8 (11.6)
BD: bipolar disorder; BDI: bipolar disorder type I; BDII: bipolar disorder type II; P1: wild-type homozygote vs. heterozygote genotype; : wild-type homozygote vs. mutant homozygote; : heterozygote vs. mutant homozygote. and represent the amount of Chi-square and asymptotic significance (2-sided), respectively. was considered statistically significant.
