Genetic Polymorphisms in miR-137 and Its Target Genes, TCF4 and CACNA1C, Contribute to the Risk of Bipolar Disorder: A Preliminary Case-Control Study and Bioinformatics Analysis

Table 6

The effect of 3 UTR variants of TCF4 and CACNA1C on miRNA binding sites.

Gene	miRNA	SNP	Effect	Allele	Energy	Conservation
TCF4	Hsa-miR-105-3p	rs1261084	Create	C
				T	-18.66	0.002
TCF4	Hsa-miR-356	rs1261084	Break	C	-22.47	0.002
				T
TCF4	Hsa- miR-3151	rs1261084	Enhance	C	-23.24	0.036
				T	-22.26	0.036
TCF4	Hsa- miR-3180	rs1261084	Enhance	C	-19.77	0.028
				T	-21.15	0.028
CACNA1C	Hsa- miR-561-3p	rs10466907	Create	T	-6.39	0.040
				G

SNP: single-nucleotide polymorphism; miRNA: microRNA.