G Protein-Coupled Receptor Kinase 4 Is a Novel Prognostic Factor in Hepatocellular Carcinoma

Figure 1

Expression of GRK4 in paired tumoral and peritumoral tissues in HCC patients. (a) Representative immunostaining of GRK4 in tumoral and peritumoral tissues of two HCC cases (×400). GRK4 is mainly expressed in the cytoplasm and membrane both in tumor and peritumor tissues. It was differentially expressed in HCC tumor tissues and rich in peritumor tissues.(A and B) GRK4 is expressed both in tumor and peritumor tissues in case 1. (C and D) GRK4 is differentially expressed in tumor and peritumor tissues in case 2. (b) Expression of GRK4 in tumor and peritumor between the training and validation cohorts. (A) Intensity of GRK4 staining was different between tumoral and peritumoral tissues. Paired sample -test and independent sample -test showed a statistical significance in the training cohort and validation cohort, respectively. (B) Distribution of various intensity scores of GRK4 staining in tumoral and peritumoral tissues between the cohorts. test displays a significant difference between the cohorts. .

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