YTHDF2 Regulates Macrophage Polarization through NF-<i>κ</i>B and MAPK Signaling Pathway Inhibition or p53 Degradation

<div>Role of m6A “reader” YTHDF2 in polarization of M1/M2 macrophages. YTHDF2 suppression promotes polarization of M1 cells via MAPK and NF-<i>κ</i>B pathway activation. Moreover, depleting YTHDF2 stabilizes p53 mRNA and upregulates its expression, thereby inhibiting the polarization of M2 macrophages.</div>

Disease Markers

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Figure 6

Figure 6: YTHDF2 Regulates Macrophage Polarization through NF-<i>κ</i>B and MAPK Signaling Pathway Inhibition or p53 Degradation 

Disease Markers

YTHDF2 Regulates Macrophage Polarization through NF-κB and MAPK Signaling Pathway Inhibition or p53 Degradation

Figure 6