The Effect of Artificial Liver Support System on Prognosis of HBV-Derived Hepatorenal Syndrome: A Retrospective Cohort Study
Table 1
Characteristics between HBV-derived HRS and non-HBV-derived HRS.
Variates
Non-HBV-derived HRS
HBV-derived HRS
P value
298
371
Age (year)
<0.001
Male sex
208 (69.80)
282 (76.00)
0.086
Degree of HE
0.998
Without HE (%)
164 (55.0)
202 (54.4)
I
42 (14.1)
55 (14.8)
II
26 (8.7)
34 (9.2)
III
22 (7.4)
26 (7.0)
IV
44 (14.8)
54 (14.6)
Ascitic (%)
0.222
Grade 1
54 (18.10)
70 (18.90)
Grade 2
84 (28.2)
110 (29.6)
Grade 3
120 (40.3)
122 (32.9)
Missing data
40 (13.4)
69 (18.6)
MAP (mmHg)
0.021
HR
0.166
INR
1.75 (1.40-1.99)
1.84 (1.51-2.42)
<0.001
Neutrophil (%)
0.566
Albumin (g/L)
0.079
Globulin (g/L)
0.368
ALT (U/L)
36.50 (21.00-106.00)
50.50 (24.00-125.00)
0.053
AST (U/L)
63.50 (34.50-98.75)
80.50 (41.00-164.50)
0.006
Hemoglobin (g/L)
<0.001
Cystatin C (mg/L)
2.16 (1.56-3.53)
1.95 (1.34-3.24)
0.197
Urea (mmol/L)
14.53 (9.05-24.40)
13.30 (7.77-23.10)
0.284
Creatinine (mg/dL)
1.83 (1.03-2.71)
1.62 (0.93-2.64)
0.656
Serum bilirubin (mg/dL)
11.75 (2.28-22.28)
13.68 (3.17-24.88)
0.073
GGT (U/L)
70.00 (32.00-152.00)
59.00 (34.00-122.00)
0.107
Potassium (mmol/L)
0.281
Sodium (mmol/L)
0.049
MELDs
0.742
iMELD
0.179
CTP
0.122
CLIF-ACLFs
0.278
CLIF-SOFAs
0.620
COSSH-ACLFs
0.648
Liver failure
146 (49.0)
198 (53.4)
0.295
Coagulation failure
42 (14.1)
84 (22.6)
0.007
Cerebral failure
66 (22.1)
80 (21.6)
0.930
ALT: alanine aminotransferase; CLIF-SOFA: Chronic Liver Failure-Sequential Organ Failure Assessment; COSSH-ACLF: Chinese Group on the Study of Severe Hepatitis B-Acute-on-Chronic Liver Failure; HBV: hepatitis B virus; INR: international normalized ratio; MAP: mean arterial pressure; MELD: Model for End-Stage Liver Disease.
