Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein

Table 3

Routine laboratory findings and multiplex quantifications after 7 days hospitalization in patients with an adverse disease evolution (death/ICU admitted) vs. all the other patients. Data are expressed as medians (IQR). Bold text highlights the statistically significant results.

Laboratory findings after 7 days ()	Adverse disease evolution ()	All other patients ()		value
Hemoglobin (g/dL)	13.5 [11.8-13.9]	13.5 [12.6-14.8]	-1.3108	0.1899
RDW-CV (%)	13.4 [12.9-14.0]	13.0 [12.6-13.8]	1.3590	0.1742
White blood cells ()	10.42 [6.96-13.04]	9.49 [7.52-11.02]	0.6708	0.5023
Neutrophils ()	9.21 [6.18-11.81]	7.24 [5.70-8.99]	1.9144	0.0556
Eosinophils ()	0.01 [0.01-0.02]	0.02 [0.01-0.08]	-1.2358	0.2165
Lymphocytes ()	0.46 [0.28-0.64]	1.38 [0.76-1.94]	-4.2958	0.0001
Neutrophil/lymphocyte ratio	19.64 [12.98-33.23]	6.23 [3.19-10.63]	4.8488	0.0001
Platelets ()	295 [214-323]	347 [289-415]	-3.1070	0.0019
ALT (U/L)	48 [31-130]	58 [37-98]	-0.3288	0.7423
AST (U/L)	33 [25-60]	29 [23-44]	0.9947	0.3199
Bilirubin (mg/dL)	0.8 [0.6-0.9]	0.6 [0.5-0.9]	1.0531	0.2923
Creatinine (mg/dL)	0.78 [0.60-1.09]	0.71 [0.61-0.84]	0.8046	0.4210
Glomerular filtration rate (mL/min)	93 [68-101]	97 [88-105]	-1.4266	0.1537
CRP (mg/dL)	3.7 [2.7-9.8]	1.0 [0.3-2.3]	4.7086	0.0001
LDH (U/L)	687 [540-892]	575 [469-666]	2.7176	0.0066
Erythrocyte sedimentation rate (mm/h)	58 [41-66]	29 [16-46]	2.8219	0.0048
Troponin I (ng/mL)	6 [3-34]	4 [2-8]	2.1054	0.0353
Ferritin (ng/mL)	933 [734-1912]	719 [379-1017]	2.2958	0.0217
D-dimer (μg/L)	1718 [1117-6381]	1001 [594-1811]	2.5272	0.0115
Albumin (g/dL)	3.4 [3.2-3.5]	3.6 [3.4-3.8]	-1.4590	0.1446
Eotaxin (pg/mL)	4.15 [3.04-5.79]	5.07 [3.62-7.40]	-1.1539	0.2485
FGF (pg/mL)	18.09 [12.68-25.30]	21.36 [10.82-28.33]	-0.2850	0.7756
G-CSF (pg/mL)	121.15 [89.00-192.46]	79.31 [61.47-103.07]	3.1603	0.0016
GM-CSF (pg/mL)	0.00 [0.00-0.00]	0.00 [0.00-0.00]	-0.6118	0.5407
IFN-γ (pg/mL)	9.70 [6.61-38.83]	6.83 [4.27-10.50]	2.2561	0.0241
IL-1β (pg/mL)	0.16 [0.00-1.80]	0.38 [0.00-1.43]	-0.7482	0.4544
IL1-RA (pg/mL)	0.00 [0.00-135.38]	0.00 [0.00-135.38]	0.3655	0.7147
IL-2 (pg/mL)	2.01 [0.00-3.74]	0.79 [0.00-3.42]	-0.1423	0.8869
IL-4 (pg/mL)	0.32 [0.00-0.84]	0.68 [0.14-1.10]	-0.6687	0.5037
IL-5 (pg/mL)	0.00 [0.00-72.05]	0.00 [0.00-72.05]	-0.1147	0.9087
IL-6 (pg/mL)	11.51 [9.12-28.52]	3.34 [0.00-8.50]	3.8190	0.0001
IL-7 (pg/mL)	5.55 [0.00-9.00]	8.57 [0.00-22.26]	-0.7029	0.4821
IL-8 (pg/mL)	28.59 [15.89-54.90]	11.02 [6.49-19.72]	3.6798	0.0002
IL-9 (pg/mL)	460.16 [316.26-488.06]	460.82 [404.15-524.46]	-0.8905	0.3732
IL-10 (pg/mL)	1.25 [0.00-3.70]	1.25 [0.00-4.42]	-0.0189	0.9849
IL-12 (pg/mL)	0.95 [0.00-1.73]	1.58 [0.00-4.68]	-1.1909	0.2337
IL-13 (pg/mL)	0.00 [0.00-0.49]	0.00 [0.00-0.78]	-0.1755	0.8607
IL-15 (pg/mL)	0.00 [0.00-0.00]	0.00 [0.00-203.24]	-1.2231	0.2213
IL-17 (pg/mL)	3.93 [3.42-5.43]	4.87 [3.65-6.49]	-0.6190	0.5360
IP-10 (pg/mL)	2893.33 [2672.14-6710.26]	737.64 [396.95-1440.44]	4.6502	0.0001
MCP-1 (pg/mL)	335.38 [106.19-712.15]	60.87 [42.11-103.27]	3.8958	0.0001
MIP-1α (pg/mL)	3.55 [2.56-5.64]	2.26 [1.51-3.02]	3.0059	0.0027
MIP-1β (pg/mL)	230.67 [180.96-234.94]	231.62 [202.97-256.98]	-1.1378	0.2552
PDGF (pg/mL)	1622.08 [622.51-2464.00]	2270.91 [1399.66-3625.82]	-1.6820	0.0926
RANTES (pg/mL)	5444.86 [2013.72-10073.76]	7544.65 [4221.08-12495.32]	-1.2120	0.2256
TNF-α (pg/mL)	18.41 [13.91-19.89]	24.04 [17.03-28.63]	-2.4685	0.0136
VEGF (pg/mL)	75.81 [0.00-264.14]	119.46 [0.00-210.59]	0.0444	0.9646