Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein

Table 7

Baseline routine laboratory findings and multiplex quantifications in patients who had a faster clinical recovery (discharged or reaching for at least 24 hours within 14 days) vs. all the other patients. Data are expressed as medians (IQR). Bold text highlights the statistically significant results.

Laboratory findings at baseline ()	Faster clinical recovery ()	All other patients ()		value
Hemoglobin (g/dL)	14.3 [12.9-15.1]	13.9 [12.4-15.0]	1.0547	0.2916
RDW-CV (%)	13.2 [12.7-13.8]	13.7 [13.0-14.4]	-2.9173	0.0035
White blood cells ()	6.80 [4.91-9.09]	7.80 [5.24-10.06]	-1.2448	0.2132
Neutrophils ()	5.39 [4.09-7.73]	6.50 [4.25-9.59]	-1.3910	0.1642
Eosinophils ()	0.00 [0.00-0.00]	0.00 [0.00-0.00]	-0.1312	0.8956
Lymphocytes ()	0.74 [0.57-0.99]	0.65 [0.44-0.89]	1.9738	0.0484
Neutrophil/lymphocyte ratio	7.62 [4.62-10.26]	10.16 [5.63-16.94]	-2.4407	0.0147
Platelets ()	219 [175-284]	186 [155-223]	2.7953	0.0052
ALT (U/L)	41 [29-56]	33 [23-52]	1.7894	0.0735
AST (U/L)	42 [31-54]	41 [33-63]	-0.6809	0.4959
Bilirubin (mg/dL)	0.6 [0.5-0.8]	0.6 [0.5-0.8]	0.2432	0.8078
Creatinine (mg/dL)	0.78 [0.62-0.88]	0.86 [0.67-1.13]	-2.5478	0.0108
Glomerular filtration rate (mL/min)	95 [78-105]	73 [62-91]	4.1183	<0.0001
CRP (mg/dL)	7.3 [4.1-11.9]	9.7 [5.3-15.4]	-2.1905	0.0285
LDH (U/L)	688 [533-870]	780 [629-904]	-1.4145	0.1572
Erythrocyte sedimentation rate (mm/h)	40 [29-50]	42 [26-56]	-0.8566	0.3916
Troponin I (ng/mL)	7 [2-13]	12 [4-30]	-2.3845	0.0171
Ferritin (ng/mL)	826 [371-1278]	1032 [465-1650]	-1.1114	0.2664
D-dimer (μg/L)	660 [449-1088]	873 [577-1377]	-2.0546	0.0399
Albumin (g/dL)	4.0 [3.6-4.2]	4.0 [3.8-4.2]	-0.2944	0.7685
Eotaxin (pg/mL)	3.59 [2.48-4.62]	3.57 [2.99-5.71]	-1.1962	0.2316
FGF (pg/mL)	12.68 [4.55-21.63]	16.61 [4.55-23.26]	-0.6986	0.4848
G-CSF (pg/mL)	59.83 [40.36-86.73]	71.35 [52.62-109.62]	-1.8984	0.0577
GM-CSF (pg/mL)	0.00 [0.00-0.00]	0.00 [0.00-0.00]	1.4044	0.1602
IFN-γ (pg/mL)	6.61 [4.73-9.59]	7.69 [5.61-11.05]	-1.6863	0.0917
IL-1β (pg/mL)	0.35 [0.00-1.43]	0.53 [0.14-1.84]	-0.8948	0.3709
IL1-RA (pg/mL)	0.00 [0.00-135.38]	0.00 [0.00-226.94]	-1.2088	0.2267
IL-2 (pg/mL)	1.06 [0.00-3.74]	1.06 [0.00-4.36]	-0.5243	0.6001
IL-4 (pg/mL)	0.32 [0.00-0.68]	0.63 [0.00-0.99]	-2.1481	0.0317
IL-5 (pg/mL)	0.00 [0.00-102.42]	0.00 [0.00-114.12]	-0.1084	0.9136
IL-6 (pg/mL)	7.66 [3.13-19.51]	17.87 [8.17-39.87]	-3.3250	0.0009
IL-7 (pg/mL)	7.44 [1.93-18.09]	8.57 [1.93-25.07]	-1.1357	0.2561
IL-8 (pg/mL)	15.26 [10.84-25.05]	22.04 [16.50-35.79]	-3.6703	0.0002
IL-9 (pg/mL)	446.49 [391.10-529.21]	469.28 [405.64-539.06]	-0.3455	0.7297
IL-10 (pg/mL)	1.25 [0.00-3.91]	2.28 [0.52-5.67]	-2.1681	0.0302
IL-12 (pg/mL)	2.21 [0.00-4.68]	1.65 [0.00-3.96]	0.7296	0.4657
IL-13 (pg/mL)	0.00 [0.00-0.49]	0.24 [0.00-0.68]	-1.4539	0.1460
IL-15 (pg/mL)	0.00 [0.00-229.24]	0.00 [0.00-271.68]	-0.6564	0.5116
IL-17 (pg/mL)	4.37 [2.91-5.95]	4.41 [3.33-6.20]	-0.6518	0.5145
IP-10 (pg/mL)	3117.30 [1993.37-5384.47]	6964.02 [4616.95-10457.34]	-5.2205	<0.0001
MCP-1 (pg/mL)	73.46 [40.74-99.83]	110.84 [52.14-203.81]	-2.8661	0.0042
MIP-1α (pg/mL)	1.59 [0.95-2.40]	1.95 [1.26-3.25]	-2.0564	0.0397
MIP-1β (pg/mL)	226.33 [194.67-253.07]	224.25 [193.76-263.00]	-0.2658	0.7904
PDGF (pg/mL)	1294.37 [719.67-2587.88]	1399.54 [653.99-2487.55]	0.0775	0.9382
RANTES (pg/mL)	5290.36 [3133.84-10501.29]	5729.65 [2483.56-9480.44]	0.1617	0.8716
TNF-α (pg/mL)	21.28 [15.42-25.97]	20.10 [15.42-25.97]	0.0709	0.9435
VEGF (pg/mL)	168.66 [0.00-273.00]	211.99 [58.45-287.78]	-0.8201	0.4121