Disease Markers / 2022 / Article / Tab 7 / Research Article
Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein Table 7 Baseline routine laboratory findings and multiplex quantifications in patients who had a faster clinical recovery (discharged or reaching
for at least 24 hours within 14 days) vs. all the other patients. Data are expressed as medians (IQR). Bold text highlights the statistically significant results.
Laboratory findings at baseline ( ) Faster clinical recovery ( ) All other patients ( ) valueHemoglobin (g/dL) 14.3 [12.9-15.1] 13.9 [12.4-15.0] 1.0547 0.2916 RDW-CV (%) 13.2 [12.7-13.8] 13.7 [13.0-14.4] -2.9173 0.0035 White blood cells ( ) 6.80 [4.91-9.09] 7.80 [5.24-10.06] -1.2448 0.2132 Neutrophils ( ) 5.39 [4.09-7.73] 6.50 [4.25-9.59] -1.3910 0.1642 Eosinophils ( ) 0.00 [0.00-0.00] 0.00 [0.00-0.00] -0.1312 0.8956 Lymphocytes ( ) 0.74 [0.57-0.99] 0.65 [0.44-0.89] 1.9738 0.0484 Neutrophil/lymphocyte ratio 7.62 [4.62-10.26] 10.16 [5.63-16.94] -2.4407 0.0147 Platelets ( ) 219 [175-284] 186 [155-223] 2.7953 0.0052 ALT (U/L) 41 [29-56] 33 [23-52] 1.7894 0.0735 AST (U/L) 42 [31-54] 41 [33-63] -0.6809 0.4959 Bilirubin (mg/dL) 0.6 [0.5-0.8] 0.6 [0.5-0.8] 0.2432 0.8078 Creatinine (mg/dL) 0.78 [0.62-0.88] 0.86 [0.67-1.13] -2.5478 0.0108 Glomerular filtration rate (mL/min) 95 [78-105] 73 [62-91] 4.1183 <0.0001 CRP (mg/dL) 7.3 [4.1-11.9] 9.7 [5.3-15.4] -2.1905 0.0285 LDH (U/L) 688 [533-870] 780 [629-904] -1.4145 0.1572 Erythrocyte sedimentation rate (mm/h) 40 [29-50] 42 [26-56] -0.8566 0.3916 Troponin I (ng/mL) 7 [2-13] 12 [4-30] -2.3845 0.0171 Ferritin (ng/mL) 826 [371-1278] 1032 [465-1650] -1.1114 0.2664 D-dimer (μ g/L) 660 [449-1088] 873 [577-1377] -2.0546 0.0399 Albumin (g/dL) 4.0 [3.6-4.2] 4.0 [3.8-4.2] -0.2944 0.7685 Eotaxin (pg/mL) 3.59 [2.48-4.62] 3.57 [2.99-5.71] -1.1962 0.2316 FGF (pg/mL) 12.68 [4.55-21.63] 16.61 [4.55-23.26] -0.6986 0.4848 G-CSF (pg/mL) 59.83 [40.36-86.73] 71.35 [52.62-109.62] -1.8984 0.0577 GM-CSF (pg/mL) 0.00 [0.00-0.00] 0.00 [0.00-0.00] 1.4044 0.1602 IFN-γ (pg/mL) 6.61 [4.73-9.59] 7.69 [5.61-11.05] -1.6863 0.0917 IL-1β (pg/mL) 0.35 [0.00-1.43] 0.53 [0.14-1.84] -0.8948 0.3709 IL1-RA (pg/mL) 0.00 [0.00-135.38] 0.00 [0.00-226.94] -1.2088 0.2267 IL-2 (pg/mL) 1.06 [0.00-3.74] 1.06 [0.00-4.36] -0.5243 0.6001 IL-4 (pg/mL) 0.32 [0.00-0.68] 0.63 [0.00-0.99] -2.1481 0.0317 IL-5 (pg/mL) 0.00 [0.00-102.42] 0.00 [0.00-114.12] -0.1084 0.9136 IL-6 (pg/mL) 7.66 [3.13-19.51] 17.87 [8.17-39.87] -3.3250 0.0009 IL-7 (pg/mL) 7.44 [1.93-18.09] 8.57 [1.93-25.07] -1.1357 0.2561 IL-8 (pg/mL) 15.26 [10.84-25.05] 22.04 [16.50-35.79] -3.6703 0.0002 IL-9 (pg/mL) 446.49 [391.10-529.21] 469.28 [405.64-539.06] -0.3455 0.7297 IL-10 (pg/mL) 1.25 [0.00-3.91] 2.28 [0.52-5.67] -2.1681 0.0302 IL-12 (pg/mL) 2.21 [0.00-4.68] 1.65 [0.00-3.96] 0.7296 0.4657 IL-13 (pg/mL) 0.00 [0.00-0.49] 0.24 [0.00-0.68] -1.4539 0.1460 IL-15 (pg/mL) 0.00 [0.00-229.24] 0.00 [0.00-271.68] -0.6564 0.5116 IL-17 (pg/mL) 4.37 [2.91-5.95] 4.41 [3.33-6.20] -0.6518 0.5145 IP-10 (pg/mL) 3117.30 [1993.37-5384.47] 6964.02 [4616.95-10457.34] -5.2205 <0.0001 MCP-1 (pg/mL) 73.46 [40.74-99.83] 110.84 [52.14-203.81] -2.8661 0.0042 MIP-1α (pg/mL) 1.59 [0.95-2.40] 1.95 [1.26-3.25] -2.0564 0.0397 MIP-1β (pg/mL) 226.33 [194.67-253.07] 224.25 [193.76-263.00] -0.2658 0.7904 PDGF (pg/mL) 1294.37 [719.67-2587.88] 1399.54 [653.99-2487.55] 0.0775 0.9382 RANTES (pg/mL) 5290.36 [3133.84-10501.29] 5729.65 [2483.56-9480.44] 0.1617 0.8716 TNF-α (pg/mL) 21.28 [15.42-25.97] 20.10 [15.42-25.97] 0.0709 0.9435 VEGF (pg/mL) 168.66 [0.00-273.00] 211.99 [58.45-287.78] -0.8201 0.4121