Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein

Table 8

Routine laboratory findings and multiplex quantifications after 7 days of hospitalization in patients who had a faster clinical recovery (discharged or reaching for at least 24 hours within 14 days) vs. all the other patients. Data are expressed as median (IQR). Bold text highlights the statistically significant results.

Laboratory findings after 7 days ()	Faster clinical recovery ()	All other patients ()		value
Hemoglobin (g/dL)	13.5 [12.5-15.0]	13.6 [12.3-14.2]	0.9946	0.3199
RDW-CV (%)	13.0 [12.5-13.6]	13.4 [12.9-13.9]	-2.1164	0.0343
White blood cells ()	9.40 [7.22-10.91]	10.36 [8.32-12.13]	-1.7866	0.0740
Neutrophils ()	6.79 [5.59-8.37]	8.99 [7.22-10.55]	-3.3804	0.0007
Eosinophils ()	0.02 [0.01-0.08]	0.02 [0.00-0.04]	1.3076	0.1910
Lymphocytes ()	1.50 [0.85-1.95]	0.62 [0.39-1.03]	4.4788	0.0001
Neutrophil/lymphocyte ratio	4.82 [3.16-8.98]	13.19 [7.74-32.29]	-4.8490	0.0001
Platelets ()	348 [303-417]	302 [260-371]	2.2241	0.0261
ALT (U/L)	63 [38-112]	41 [27-69]	2.4130	0.0158
AST (U/L)	30 [24-45]	30 [23-40]	0.5323	0.5945
Bilirubin (mg/dL)	0.6 [0.5-0.9]	0.7 [0.6-0.9]	-0.3411	0.7330
Creatinine (mg/dL)	0.72 [0.62-0.85]	0.73 [0.55-0.83]	0.5298	0.5963
Glomerular filtration rate (mL/min)	98 [88-107]	91 [69-102]	1.9951	0.0460
CRP (mg/dL)	0.8 [0.3-1.9]	3.7 [2.3-7.8]	-6.1875	<0.0001
LDH (U/L)	551 [449-650]	645 [561-819]	-3.3632	0.0008
Erythrocyte sedimentation rate (mm/h)	25 [16-43]	50 [32-63]	-3.1074	0.0019
Troponin I (ng/mL)	4 [2-7]	6 [3-22]	-2.2200	0.0264
Ferritin (ng/mL)	751 [452-998]	793 [520-1346]	-1.2909	0.1968
D-dimer (μg/L)	903 [567-1438]	1755 [1132-2639]	-3.5792	0.0003
Albumin (g/dL)	3.6 [3.4-3.8]	3.4 [3.2-3.7]	1.9968	0.0458
Eotaxin (pg/mL)	5.06 [3.59-7.92]	4.26 [3.68-6.09]	0.8166	0.4142
FGF (pg/mL)	19.63 [10.82-28.33]	20.40 [12.68-28.66]	-0.3791	0.7046
G-CSF (pg/mL)	78.28 [59.83-98.47]	93.75 [77.86-156.42]	-2.5911	0.0096
GM-CSF (pg/mL)	0.00 [0.00-0.00]	0.00 [0.00-0.00]	1.7318	0.0833
IFN-γ (pg/mL)	6.14 [3.82-9.72]	9.57 [6.61-13.09]	-2.8483	0.0044
IL-1β (pg/mL)	0.38 [0.00-1.09]	0.59 [0.00-1.43]	-0.3944	0.6933
IL1-RA (pg/mL)	0.00 [0.00-117.10]	0.00 [0.00-168.65]	-1.1670	0.2432
IL-2 (pg/mL)	0.79 [0.00-2.77]	2.01 [0.00-4.22]	-0.5259	0.5989
IL-4 (pg/mL)	0.58 [0.14-0.92]	0.68 [0.00-1.10]	-0.2517	0.8013
IL-5 (pg/mL)	0.00 [0.00-72.05]	0.00 [0.00-72.05]	0.2073	0.8357
IL-6 (pg/mL)	2.13 [0.00-6.63]	9.60 [5.39-17.71]	-4.3785	0.0001
IL-7 (pg/mL)	1.93 [0.00-18.09]	9.00 [0.91-22.56]	-1.4369	0.1507
IL-8 (pg/mL)	9.42 [6.49-14.56]	21.19 [11.85-28.97]	-4.0087	0.0001
IL-9 (pg/mL)	460.38 [403.05-520.05]	460.82 [368.17-516.36]	0.1341	0.8933
IL-10 (pg/mL)	0.97 [0.00-3.63]	2.05 [0.10-4.88]	-1.3278	0.1842
IL-12 (pg/mL)	1.34 [0.00-3.96]	1.56 [0.00-3.96]	0.0000	1.0000
IL-13 (pg/mL)	0.00 [0.00-0.79]	0.00 [0.00-0.35]	0.6089	0.5426
IL-15 (pg/mL)	0.00 [0.00-172.77]	0.00 [0.00-84.08]	0.6610	0.5029
IL-17 (pg/mL)	4.73 [3.65-6.49]	4.94 [3.42-6.37]	-0.1294	0.8970
IP-10 (pg/mL)	668.26 [377.20-1164.56]	1897.80 [1022.41-4465.42]	-4.4249	0.0001
MCP-1 (pg/mL)	59.34 [38.81-100.05]	106.19 [60.87-359.83]	-3.2373	0.0012
MIP-1α (pg/mL)	2.23 [1.51-2.69]	3.25 [2.40-4.36]	-3.5158	0.0004
MIP-1β (pg/mL)	234.90 [207.93-256.98]	230.67 [181.26-246.32]	0.9721	0.3310
PDGF (pg/mL)	2270.91 [1463.58-3558.49]	1918.40 [929.93-3491.39]	0.9099	0.3629
RANTES (pg/mL)	7255.70 [4279.12-12430.58]	7635.33 [2738.21-10391.71]	0.5172	0.6050
TNF-α (pg/mL)	23.77 [16.92-28.63]	19.89 [15.42-25.97]	1.1116	0.2663
VEGF (pg/mL)	105.40 [0.00-188.97]	119.46 [0.00-264.76]	-1.0418	0.2975