Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein

<table class="table-group" id="tab9"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td class="align_left">Prognostic biomarkers (<span class="nowrap"><svg height="8.55521pt" id="M98" style="vertical-align:-0.2063904pt" version="1.1" viewbox="-0.0498162 -8.34882 10.8126 8.55521" width="10.8126pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M324 430H196L233 583L223 592L145 529L120 430H54L29 396L31 388H111L56 126C33 15 54 -12 77 -12C137 -12 214 57 250 95L233 119C208 92 155 59 138 59C126 59 120 70 131 125L186 390L298 394L324 430Z"></path></g><g transform="matrix(.013,0,0,-0.013,4.433,0)"><path d="M241 635C89 635 35 457 35 312C35 153 89 -12 240 -12C390 -12 443 166 443 312C443 466 390 635 241 635ZM238 602C329 602 354 454 354 312C354 172 330 22 240 22C152 22 124 173 124 313S148 602 238 602Z"></path></g></svg>)</span></td><td class="align_center"><span style="width: 13.76ptpx;"><svg height="13.532pt" id="M99" style="vertical-align:-3.4295pt" version="1.1" viewbox="-0.0498162 -10.1025 13.76 13.532" width="13.76pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M558 587C558 666 497 712 432 712C379 712 330 691 284 650C212 586 178 508 148 348L71 -65C49 -185 35 -229 23 -235L27 -261C49 -259 101 -251 124 -224C131 -216 138 -178 159 -24C171 66 197 200 227 356C264 550 295 668 393 668C443 668 479 632 479 575C479 516 446 458 383 418C361 404 344 398 318 397L296 350C395 338 460 281 460 192C460 110 411 40 300 40C258 40 215 55 192 69L181 51C191 18 222 -16 266 -16C308 -16 351 1 397 26C471 67 545 142 545 221C545 315 486 365 401 395C469 437 558 498 558 587Z"></path></g><g transform="matrix(.0091,0,0,-0.0091,7.554,-5.741)"><path d="M486 158C486 177 478 202 466 220C413 228 386 236 336 262C386 288 413 297 466 304C478 323 486 347 485 366C470 376 444 381 422 380C389 338 368 319 321 288C323 345 329 372 349 422C339 442 322 461 305 470C289 461 271 442 262 422C281 372 287 345 290 288C243 319 222 338 189 380C167 381 142 376 125 366C125 347 133 322 145 304C198 296 225 288 275 262C225 236 198 227 145 220C133 201 125 177 126 158C141 148 167 143 189 144C222 186 243 205 290 236C288 179 282 152 262 102C272 82 289 63 306 54C322 63 340 82 350 102C330 152 324 179 321 236C368 205 390 186 422 144C444 143 470 148 486 158Z"></path></g></svg></span></td><td class="align_center"><svg height="10.2124pt" id="M100" style="vertical-align:-3.42943pt" version="1.1" viewbox="-0.0498162 -6.78297 7.83752 10.2124" width="7.83752pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M570 304C570 398 525 448 414 448C385 448 343 445 312 434L329 511L321 518C297 504 262 482 244 460L233 411C195 397 159 381 128 358L135 332C160 347 189 360 224 373L111 -147C97 -210 84 -218 17 -231L13 -257L254 -247L259 -218L233 -216C183 -212 177 -202 189 -142L218 -1C238 -10 266 -12 283 -12C351 3 429 48 483 105C543 168 570 242 570 304ZM482 289C482 161 380 33 304 33C278 33 248 51 233 69L303 396C326 400 352 403 369 403C428 403 482 380 482 289Z"></path></g></svg> value</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td class="align_left">Glomerular filtration rate</td><td class="align_center"><b>0.3828</b></td><td class="align_center"><b>0.0046</b></td></tr><tr><td class="align_left">IP-10</td><td class="align_center"><b>-0.2388</b></td><td class="align_center"><b>0.0226</b></td></tr><tr><td class="align_left">Neutrophil/lymphocyte ratio</td><td class="align_center"><b>-0.2033</b></td><td class="align_center"><b>0.0138</b></td></tr><tr><td class="align_left">Creatinine</td><td class="align_center">0.2719</td><td class="align_center">0.1363</td></tr><tr><td class="align_left">RDW-CV</td><td class="align_center">-0.1229</td><td class="align_center">0.1524</td></tr><tr><td class="align_left">D-dimer</td><td class="align_center">-0.1115</td><td class="align_center">0.2090</td></tr><tr><td class="align_left">IL-6</td><td class="align_center">-0.1222</td><td class="align_center">0.1952</td></tr><tr><td class="align_left">MIP-1<i>α</i></td><td class="align_center">0.2804</td><td class="align_center">0.1768</td></tr><tr><td class="align_left">MCP-1</td><td class="align_center">-0.0815</td><td class="align_center">0.4383</td></tr><tr><td class="align_left">Troponin I</td><td class="align_center">-0.0861</td><td class="align_center">0.5313</td></tr><tr><td class="align_left">IL-8</td><td class="align_center">-0.1307</td><td class="align_center">0.3177</td></tr><tr><td class="align_left">Platelets</td><td class="align_center">0.0731</td><td class="align_center">0.3932</td></tr><tr><td class="align_left">IL-10</td><td class="align_center">-0.1754</td><td class="align_center">0.5810</td></tr><tr><td class="align_left">CRP</td><td class="align_center">-0.0061</td><td class="align_center">0.9450</td></tr><tr><td class="align_left">Lymphocytes</td><td class="align_center">-0.0011</td><td class="align_center">0.9882</td></tr><tr><td class="align_left">IL-4</td><td class="align_center">0.0668</td><td class="align_center">0.8293</td></tr><tr class="table-tr"><td colspan="3"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

<div>Multivariate analysis for baseline routine laboratory findings and multiplex quantifications predicting a faster clinical recovery (hospital discharge or <svg height="9.87315pt" id="M97" style="vertical-align:-1.11981pt" version="1.1" viewbox="-0.0498162 -8.75334 56.6615 9.87315" width="56.6615pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M719 650H483V622C553 619 576 606 581 560C585 532 588 487 588 394V148H585L167 650H20V622C67 618 88 610 109 585C127 562 129 557 129 484V264C129 173 126 124 123 93C118 44 92 31 35 28V0H272V28C204 32 181 44 176 95C173 124 170 172 170 264V515H172L598 -9H629V394C629 487 631 532 635 563C639 606 663 619 719 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,9.659,0)"><path d="M517 162C503 123 484 88 467 68C445 42 417 34 341 34C291 34 256 34 237 47C219 59 213 81 213 128V317H308C395 317 402 311 415 240H444V431H415C403 364 398 356 307 356H213V584C213 613 215 616 246 616H322C394 616 421 609 435 587C448 566 458 544 467 502L496 506C493 557 488 625 488 650H42V622C120 616 128 612 128 523V125C128 43 120 35 29 28V0H511C520 31 540 125 546 158L517 162Z"></path></g><g transform="matrix(.013,0,0,-0.013,16.886,0)"><path d="M956 650H736V622C814 613 818 602 804 542C789 471 733 275 691 141H689C628 314 570 476 514 641H485C434 478 377 312 323 142H321C277 284 238 419 199 554C184 605 186 613 259 622V650H16V622C77 615 92 606 117 524C172 346 228 170 281 -11H312C363 151 419 312 475 488H477C528 343 597 150 652 -11H683C765 269 826 458 848 522C878 605 887 613 956 622V650Z"></path></g><g transform="matrix(.013,0,0,-0.013,29.079,0)"><path d="M409 504C401 567 396 607 392 642C354 654 312 665 266 665C137 665 60 583 60 487C60 374 161 325 225 290C300 250 355 215 355 141C355 68 311 21 235 21C131 21 86 122 71 183L41 176C48 128 61 42 68 21C78 16 93 8 118 0C142 -7 175 -15 216 -15C349 -15 438 69 438 174C438 287 344 333 265 374C186 414 138 449 138 522C138 576 172 631 249 631C336 631 363 562 380 499L409 504Z"></path></g><g transform="matrix(.013,0,0,-0.013,39.007,0)"><path d="M531 71V127L115 310L531 494V550L57 335V285L531 71ZM531 -40V10H57V-40H531Z"></path></g><g transform="matrix(.013,0,0,-0.013,50.27,0)"><path d="M412 140C382 77 369 73 315 73H129L270 222C362 320 402 379 402 466C402 571 322 635 234 635C177 635 130 609 99 576L42 495L64 475C90 514 133 568 201 568C274 568 318 519 318 435C318 349 255 267 193 193C144 135 87 78 32 23V0H405C417 45 427 89 440 131L412 140Z"></path></g></svg> within 14 days of hospitalization). Bold text highlights the statistically significant results.</div>

Disease Markers

tab9

Table 9

Table 9: Prognostic Markers in Hospitalized COVID-19 Patients: The Role of IP-10 and C-Reactive Protein 