Overexpression of Stathmin 1 Predicts Poor Prognosis and Promotes Cancer Cell Proliferation and Migration in Ovarian Cancer

Figure 4

Bioinformatic analysis revealed that STMN1 was potentially regulated by E2F transcription factors. (a) A bubble chart showing the pathways of gene set enrichment analysis (GSEA). (b) GSEA showed that the gene sets associated with E2F targets were enriched in the OA samples with higher STMN1 expression. (c) Metascape analysis showed that the gene sets positively correlated with STMN1 were predicted to be regulated by E2F transcription factors in the ovarian cancer samples. (d) The expression level of STMN1 was found to be positively associated with E2F1 expression in ovarian cancer. (e) JASPAR predicted the STMN1 promoter sequence targeted by E2F1.

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