The Association of Long-Term Use of Proton Pump Inhibitors and Histamine H₂ Receptor Antagonists with Clinical Complications in Patients with Severe Sepsis

Table 1

Basic information of experimental patients.

Characteristic		Total (%)	PPIs (in ICU) (%)	H2 blockers (in ICU) (%)	value
Total number		208188	162016 (56.97)	46172 (23.79)	0.013
Mean age (SD) (years)		65.10 (12.25)	64.29 (11.39)	63.92 (10.11)	0.37
Male		204357 (96.11)	159396 (96.28)	44961 (95.29)	0.014
Female		3831 (4.07)	2620 (4.01)	1211 (4.11)	0.019
Admission in hospital in the last one year		18800 (8.81)	15328 (8.78)	3472 (8.83)	0.008
Length of hospital stay inpatients (IQR) median in days		7 (4 to 14)	7 (5 to 15)	7 (4 to 14)	0.17
No. of outpatient visits (IQR)		5 (2 to 11)	5 (2 to 11)	5 (2 to 11)	0.52
Smoking	Current	37263 (19.11)	26387 (18.39)	10876 (21.76)	0.009
	Former	37732 (20.09)	28967 (20.87)	8765 (19.38)	0.011
	Never	115325 (57.96)	87229 (56.03)	28096 (58.96)	<0.001