Predictive Value of Monocyte Chemoattractant Protein-1 in the Development of Diastolic Dysfunction in Patients with Psoriatic Arthritis

Table 2

Clinical and laboratory characteristics of PsA patients classified into groups with respect to the cut-off MCP-1 concentration (347.6 pg/mL).

	Patients with serum MCP-1		value
	≤347.6 pg/mL (); Median; 25^th; 75^th percentiles	>347.6 pg/mL (); Median; 25^th; 75^th percentiles
Clinical characteristics and laboratory parameters
BASDAI	3.1 (1.05; 3.94)	4 (2.7; 4.95)	0.236^a
BASFI	1.75 (1.1; 2.8)	2 (1.35; 5.6)	0.19^a
DAPSA	10.6 (8.3; 18.5)	18.45 (11.77; 32.35)	0.0000^a
BSA (%)	0.25 (0; 1)	0 (0; 2)	0.572^a
BMI (kg/m^2)	26.9 (25.65; 29.9)	30.3 (27.15; 33.8)	0.082^a
Diastolic pressure (mmHg)	85 (77.25; 92.75)	89.5 (80; 100)	0.1^a
Systolic pressure (mmHg)	129.5 (102; 180)	150 (128.75; 159.25)	0.01^a
CRP (mg/L)	1.2 (0.8; 2.8)	1.65 (0.95; 9.1)	0.249^a
Glucose (mmol/L)	5.2 (4.9; 5.65)	5.8 (5.3; 6.5)	0.011^a
LDL-cholesterol (mmol/L)	3.7 (3; 4.1)	4 (3.57; 5.17)	0.012^a
NT-pro-BNP (pmol/L)	60 (35; 136)	57 (42; 62.25)	0.803^a
MCP-1 (pg/L)	267.7 (214.2; 299.2)	404.1 (391; 422.9)	0.00063^a
Age (year)	61 (54; 64)	62 (55.75; 67.25)	0.478^a
Comorbidities and current therapy ()
Type II diabetes	4	3	0.503^b
Arterial hypertension	21	14	0.115^b
Cigarette smoking	7	6	0.210^b
sDMARD	13	7	0.705^b
TNF inhibitors	13	10	0.129^b
NSAR	17	3	0.051^b
ACE inhibitors	8	7	0.155^b
Beta blockers	11	9	0.123^b

MCP-1: Monocyte Chemoattractant Protein-1; BASDAI: Bath Ankylosing Spondylitis Disease Activity Index; BASFI: Bath Ankylosing Spondylitis Functional Index; DAPSA: Disease Activity in Psoriatic Arthritis; BSA: body surface area; BMI: body mass index; NYHA: New York Heart Association Classification; LDL: low-density lipoprotein; NT-pro-BNP: N-terminal probrain natriuretic peptide; sDMARD: synthetic disease-modifying antirheumatic drugs; TNF: tumor necrosis factor; NSAR: nonsteroid antirheumatics; ACE: angiotensin-converting enzyme. Levels of statistical significance are indicated as values in ^aMann–Whitney test; ^bChi-squared test.