Ferulic Acid Mitigates Growth and Invasion of Esophageal Squamous Cell Carcinoma through Inducing Ferroptotic Cell Death

Figure 7

DFO restrains the stimulative effect of FA on ferroptotic cell death of ESCC cells. (a, b) Iron content was measured in EC-1 and TE-4 cells with 48 h administration of 40 μM FA and 50 μM DFO. (c–g) Activities of ACSL4, SLC7A11, HO-1, and GPX4 were tested in EC-1 cells with administration of 40 μM FA and 50 μM DFO for 48 h via immunoblotting. (h–l) Activities of ACSL4, SLC7A11, HO-1, and GPX4 were monitored in TE-4 cells that were exposed to 40 μM FA and 50 μM DFO for 48 h via immunoblotting. was computed through one-way ANOVA test. Significance level was denoted as , , , and .

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