Red Cell Distribution Width to Platelet Ratio Is Associated with Increasing In-Hospital Mortality in Critically Ill Patients with Acute Kidney Injury

Table 3

Risk of in-hospital mortality in critically ill patients with acute kidney injury according to red cell distribution width to platelet ratio.

Model	Categorical variable (≥0.093 vs. <0.093)		Continuous variables
	HR (95% CI)	value	HR (95% CI)	value
Crude model	1.48 (1.42-1.55)	<0.001	2.05 (1.97-2.13)	<0.001
Model 1^a	1.48 (1.41-1.54)	<0.001	1.99 (1.91-2.07)	<0.001
Model 2^b	1.48 (1.41-1.54)	<0.001	1.98 (1.90-2.06)	<0.001
Model 3^c	1.49 (1.42-1.56)	<0.001	1.95 (1.88-2.02)	<0.001
Model 4^d	1.48 (1.42-1.56)	<0.001	1.94 (1.88-2.01)	<0.001
Model 5^e	1.47 (1.41-1.55)	<0.001	1.91 (1.84-1.99)	<0.001
Model 6^f	1.46 (1.40-1.55)	<0.001	1.88 (1.80-1.97)	<0.001

HR: hazard ratio; CI: confidence interval. ^aModel 1 was adjusted for demographic features, including age, gender, and ethnicity; ^bModel 2 was additionally adjusted for comorbidities, including congestive heart failure, chronic pulmonary, diabetes, and obesity; ^cModel 3 was additionally adjusted for laboratory examinations, including bicarbonate, bilirubin, chloride, glucose, hematocrit, hemoglobin, lactate, potassium, sodium, white blood cell, lymphocyte, neutrophile, activated partial prothrombin time, international normalized ratio, neutrophil to lymphocyte ratio, and platelet to lymphocyte ratio; ^dModel 4 was additionally adjusted for scoring systems and clinical therapies, including sequential organ failure assessment, simplified acute physiology score II, renal replacement therapy, mechanical ventilation, and vasopressor use; ^eModel 5 was additionally adjusted for vital signs, including systolic blood pressure, diastolic blood pressure, temperature, heart rate, respiratory rate, and SpO₂; ^fModel 6 was additionally adjusted for renal function, including creatinine, blood urea nitrogen, and AKI stage.