LIN28B Polymorphisms Confer a Higher Postoperative Recurrence Risk in Reproductive-Age Women with Endometrial Polyps
Table 2
The associations between LIN28B gene polymorphisms and recurrence of EP.
Genotypes
Recurrence, (%)
Nonrecurrence, (%)
for HWPa
Adjusted HR (95% CI)b
for Cox model
Subjects
44
307
rs369065 ()
CC
5 (11.4)
48 (15.6)
0.576
Ref. (1.00)
CT
16 (36.4)
160 (51.1)
1.115 (0.406-3.061)
0.833
TT
23 (52.3)
99 (32.2)
2.044 (0.768-5.442)
0.152
Dominant
39 (88.6)
259 (84.4)
1.512 (0.591-3.867)
0.388
Recessive
21 (47.7)
208 (67.8)
1.883 (1.033-3.434)
0.039
rs314280 ()
AA
3 (6.8)
30 (9.8)
0.974
Ref. (1.00)
GA
13 (29.5)
138 (45.0)
0.904 (0.249-3.275)
0.878
GG
28 (63.6)
139 (45.3)
1.613 (0.472-5.5.7)
0.446
Dominant
41 (93.2)
277 (90.2)
1.271 (0.382-4.234)
0.696
Recessive
16 (36.4)
168 (54.7)
1.751 (0.916-3.349)
0.090
aThe observed genotype frequency in the study population was in agreement with the Hardy–Weinberg equilibrium () (,. 576 for rs369065; , for rs314280). HR: hazard ratio. bAdjusted age, gravidities, menarche age, number and size of polyps, and endometrial thickness.
