Single-Cell RNA-seq Analysis Reveals Dysregulated Cell-Cell Interactions in a Tumor Microenvironment Related to HCC Development

Figure 4

Cell-cell interaction events (CCEs) between hepatocyte (cluster C2) and other cell clusters in the microenvironment. (a) Significantly enriched KEGG pathways of the markers of cluster C2. (b) The circos plot for CCE counts from hepatocyte cluster to other cell clusters in HCC. (c) Significantly enriched KEGG pathways of the ligand and receptor genes of cluster C2 in HCC. (d) Significantly enriched GO BP terms of the ligand and receptor genes of cluster C2 in HCC. (e) Dysregulated CCEs when C2 interacted with C0, C2 as the regulatory cell cluster. (f) Dysregulated CCEs when C2 interacted with C1, C2 as the regulatory cell cluster.

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