Fibromodulin Gene Variants (FMOD) as Potential Biomarkers for Prostate Cancer and Benign Prostatic Hyperplasia

Table 2

Variants found in the molecular analysis of the FMOD gene.

Gene location	SNP ID	c.DNA	Protein	Type of change	MAF	No. of individuals with alteration
						Control	BPH	PCa
Exon 2	rs115908597	c.125A>C	p.(Tyr42Ser)	Missense	<0.01	0	2	1
Exon 2	rs139299015	c.70C>G	p.(Pro24Ala)	Missense	<0.01	1	0	0
Intron 2-3	rs1891180	c.980-114A>G	—	Intronic	0.60	82	74	44
Exon 2	rs77856193	c.759C>T	p.(His253=)	Synonym	<0.01	1	0	2
Exon 2	rs7543148	c.237G>A	p.(Glu79=)	Synonym	0.40	66	70	44
Exon 3	rs145901742	c.1059C>T	p.(Asn353=)	Synonym	0.04	0	0	1

Representation of the variants found through the automatic sequencing of the FMOD gene, with its nitrogenous base and/or amino-acid base exchange characteristics, in addition to the number of individuals found with the alteration in each of the sample groups. Source: prepared by the author.