Metabolic Understanding of the Genetic Dysregulation in the Tumor Microenvironment of Kidney Renal Clear Cell Carcinoma

Figure 7

NUDT1 regulate renal cancer cell proliferation and migration. (a) NUDT1 relatively express higher in the KIRC tissues as compared to normal tissues. (b) siRNA-mediated knockdown of NUDTI in 786-O and ACHN cells. (c, d) Cell proliferation assay showing reduced proliferation of KIRC cells in siRNA-mediated silencing of the NUDTI cells. (e–h) Cell migration and cell invasion reduced in 786-O and ACHN cells after NUDTI knockdown. (i–k) Number of apoptotic cells significantly increased in knockdown cells. (l–n) Wound healing slows down in the NUDT1 knockdown cells.

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