Identification of Ferroptosis-Related Gene Prognostic Signature and HSF1 for Reversing Doxorubicin and Gemcitabine Resistance in Uterine Carcinosarcoma

Figure 5

Targeting HSF1 enhance sensitivity of doxorubicin and gemcitabine in MES-SA and FU-MMT-1 cells. (a) Western blot was used to detect the HSF1 expression after knockdown in MES-SA and FU-MMT-1 cells. (b, c) Cell viability were detected when HSF1 knockdown combined with treatment with doxorubicin in MES-SA and FU-MMT-1 cells. (d, e) Cell viability were detected when HSF1 knockdown combined with treatment with gemcitabine in MES-SA and FU-MMT-1 cells. (f–i) Colony forming ability were detected when HSF1 knockdown combined with treatment with gemcitabine or doxorubicin in MES-SA and FU-MMT-1 cells ( vs. control group, ; ^# vs. gemcitabine 1 μM or doxorubicin 1 μM group, ).

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