Research Article
Identification of the Potential Correlation between Tumor Protein 73 and Head and Neck Squamous Cell Carcinoma
Table 1
Analysis of clinical characteristics of TCGA-HNSC patients according to TP73 gene.
| | Characteristic | Low expression of TP73 | High expression of TP73 | |
| | 251 | 251 | | | T stage, (%) | | | 0.259 | | T1 | 14 (2.9%) | 19 (3.9%) | | | T2 | 63 (12.9%) | 81 (16.6%) | | | T3 | 70 (14.4%) | 61 (12.5%) | | | T4 | 94 (19.3%) | 85 (17.5%) | | | N stage, (%) | | | 0.502 | | N0 | 125 (26%) | 114 (23.8%) | | | N1 | 40 (8.3%) | 40 (8.3%) | | | N2 | 69 (14.4%) | 85 (17.7%) | | | N3 | 4 (0.8%) | 3 (0.6%) | | | M stage, (%) | | | 1.000 | | M0 | 233 (48.8%) | 239 (50.1%) | | | M1 | 2 (0.4%) | 3 (0.6%) | | | Clinical stage, (%) | | | 0.630 | | Stage I | 9 (1.8%) | 10 (2%) | | | Stage II | 48 (9.8%) | 47 (9.6%) | | | Stage III | 56 (11.5%) | 46 (9.4%) | | | Stage IV | 129 (26.4%) | 143 (29.3%) | | | Radiation therapy, (%) | | | 0.463 | | No | 73 (16.6%) | 81 (18.4%) | | | Yes | 148 (33.6%) | 139 (31.5%) | | | Primary therapy outcome, (%) | | | 0.104 | | PD | 27 (6.5%) | 14 (3.3%) | | | SD | 3 (0.7%) | 3 (0.7%) | | | PR | 4 (1%) | 2 (0.5%) | | | CR | 171 (40.9%) | 194 (46.4%) | | | Gender, (%) | | | 0.762 | | Female | 65 (12.9%) | 69 (13.7%) | | | Male | 186 (37.1%) | 182 (36.3%) | | | Race, (%) | | | 0.786 | | Asian | 4 (0.8%) | 6 (1.2%) | | | Black or African American | 22 (4.5%) | 25 (5.2%) | | | White | 213 (43.9%) | 215 (44.3%) | | | Age, (%) | | | 0.067 | | ≤60 | 112 (22.4%) | 133 (26.5%) | | | >60 | 139 (27.7%) | 117 (23.4%) | | | Histologic grade, (%) | | | 0.011 | | G1 | 40 (8.3%) | 22 (4.6%) | | | G2 | 154 (31.9%) | 146 (30.2%) | | | G3 | 50 (10.4%) | 69 (14.3%) | | | G4 | 0 (0%) | 2 (0.4%) | | | Smoker, (%) | | | 0.702 | | No | 53 (10.8%) | 58 (11.8%) | | | Yes | 192 (39%) | 189 (38.4%) | | | Alcohol history, (%) | | | 0.743 | | No | 82 (16.7%) | 76 (15.5%) | | | Yes | 166 (33.8%) | 167 (34%) | | | Lymphovascular invasion, (%) | | | 1.000 | | No | 118 (34.6%) | 101 (29.6%) | | | Yes | 65 (19.1%) | 57 (16.7%) | | | Lymphnode neck dissection, (%) | | | <0.001 | | No | 29 (5.8%) | 61 (12.2%) | | | Yes | 221 (44.3%) | 188 (37.7%) | | | OS event, (%) | | | 0.059 | | Alive | 131 (26.1%) | 153 (30.5%) | | | Dead | 120 (23.9%) | 98 (19.5%) | | | DSS event, (%) | | | 0.030 | | Alive | 165 (34.6%) | 182 (38.2%) | | | Dead | 77 (16.1%) | 53 (11.1%) | | | PFI event, (%) | | | 0.013 | | Alive | 140 (27.9%) | 168 (33.5%) | | | Dead | 111 (22.1%) | 83 (16.5%) | | | Age, median (IQR) | 62 (53, 69) | 60 (53, 68) | 0.198 |
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