Research Article
SN-38 Sensitizes BRCA-Proficient Ovarian Cancers to PARP Inhibitors through Inhibiting Homologous Recombination Repair
Figure 1
SN-38 inhibits homologous recombination repair in BRCA-proficient ovarian cancer cells. (a) Schematic diagram of HR reporter system. The expression of wild-type GFP can be rescued only by HR repair, resulting in GFP fluorescence. (b) HR repair activities were measured in cells treated with SN-38 (1 μM) or control (Ctrl). Data represent the , per group. , by 2-tailed -test. (c) Immunostaining analysis of IR-induced Rad51 in SN-38 (10 μM) treated or untreated A2780 cells. , by 2-tailed -test.
(a) |
(b) |
(c) |