U-Shape Relationship between Plasma Leucine Level and Mortality in the Intensive Care Unit
Table 1
Demographic and laboratory data in the initiation cohort.
All
Survival
Death
value
Age (years)
0.021
Male (%)
219 (62.9)
138 (59.5)
81 (69.8)
0.061
APACHE II score
<0.001
SOFA score
<0.001
Body mass index (kg/m2)
0.108
Co-morbidity
Diabetes mellitus (%)
176 (50.6)
117 (50.4)
59 (50.9)
1.000
Hypertension (%)
234 (67.2)
152 (65.5)
82 (70.7)
0.396
Coronary artery disease (%)
157 (45.1)
113 (48.7)
44 (37.9)
0.067
COPD (%)
27 (7.80)
24 (10.3)
3 (2.6)
0.010
Chronic kidney disease (%)
82 (23.6)
56 (24.1)
26 (22.4)
0.789
Ventilator use (%)
239 (68.7)
156 (67.2)
83 (71.6)
0.463
Inotropic agent use (%)
120 (34.5)
59 (25.4)
61 (52.6)
<0.001
Days in ICU (day)
0.012
Days in hospital (day)
0.326
Laboratory data
White blood cell (1000/uL)
0.152
Hemoglobin (g/dL)
0.131
C-reactive protein (mg/L)
46.6 (11.4-103)
32.6 (7.52-81.4)
66.0 (26.6-148)
<0.001
Cholesterol (mg/dL)
<0.001
Triglyceride (mg/dL)
112 (83.5-153)
112 (83.5-153)
112 (83.5-151)
0.981
eGFR (ml/min/1.73 m2)
33.5 (11.9-64.9)
38.6 (13.5-68.7)
24.0 (10.8-52.3)
0.086
ALT (U/L)
29 (17-60.7)
28.0 (16.0-54.0)
36.5 (18.0-100)
0.102
Albumin (g/dL)
<0.001
Prealbumin (mg/dL)
<0.001
Transferrin (mg/dL)
<0.001
Leucine 109-174 μM
143 (41.1)
107 (46.1)
36 (31.0)
0.008
Data are expressed as the for variables with normal distribution, median (interquartile range (IQR)) for variables with skewed distribution, and as number (percentage) for categorical variables. APACHE: acute physiology and chronic health evaluation; ALT: alanine aminotransferase; COPD: chronic obstructive pulmonary disease; chronic kidney disease: estimated glomerular filtration rate ; CRP: C-reactive protein; ICU: intensive care unit; SOFA: sequential organ failure assessment; WBC: white blood cell count.
