U-Shape Relationship between Plasma Leucine Level and Mortality in the Intensive Care Unit
Table 2
Comparisons of demographic and laboratory data in patients with different leucine concentrations in the initiation cohort.
Leucine
109-174 μM
<109 μM
>174 μM
value#
Age (years)
0.552
Male (%)
96 (67.1)
81 (54)
42 (76.3)
0.015
APACHE II score
0.041
SOFA score
0.034
Body mass index (kg/m2)
0.197
Admission to ICU
29 (20.2)
27 (18)
6 (10.9)
0.909
Comorbidity
Diabetes mellitus (%)
69 (48.2)
71 (47.3)
36 (65.4)
0.165
Hypertension (%)
98 (82.1)
100 (66.6)
36 (65.4)
0.900
Coronary artery disease (%)
69 (48.2)
59 (39.3)
29 (52.7)
0.432
Atrial fibrillation (%)
21 (14.6)
28 (18.6)
10 (18.1)
0.640
COPD (%)
14 (9.79)
12 (8.0)
1 (1.8)
0.510
Chronic kidney disease (%)
37 (25.8)
31 (20.6)
14 (25.4)
0.540
Ventilator use (%)
96 (67.1)
109 (72.6)
34 (61.8)
0.873
Inotropic agent use (%)
37 (25.8)
64 (42.6)
19 (34.5)
0.012
Days in ICU (day)
0.032
Days in hospital (day)
0.007
Laboratory data
White blood cell (1000/ul)
0.221
Hemoglobin(g/dL)
0.004
C-reactive protein (mg/L)
41.4 (8.73, 103)
45.2 (12.4, 105)
58.3 (14.6, 104)
0.760
Cholesterol (mg/dL)
†
0.010
Triglyceride (mg/dL)
119 (88, 156)
99 (77, 135)
126 (98, 180)†
0.003
eGFR (mL/min/1.73 m2)
0.922
ALT (U/L)
27 (16, 49)
27 (16, 63.5)
43 (21, 134),†
0.005
Albumin (g/dl)
†
<0.001
Prealbumin (mg/dL)
0.087
Transferrin (mg/dL)
†
<0.001
Data are expressed as the for variables with normal distribution, as the median (interquartile range) for variables with skewed distribution, and as the number (percentage) for categorical variables. #, comparisons by One-way ANOVA and Chi-square (multiple comparison with Bonferroni adjusted value). ICU: intensive care unit; COPD: chronic obstructive pulmonary disease; eGFR: estimated glomerular filtration rate; CRP: C-reactive protein; ALT: alanine aminotransferase; SOFA: sequential organ failure assessment. ,, compared to “Leucine 109-174 μM”; †, compared to “Leucine <109 μM”.
