Research Article
U-Shape Relationship between Plasma Leucine Level and Mortality in the Intensive Care Unit
Table 3
COX univariate and multivariable analysis of factors for predicting mortality in the initiation cohort.
| | Univariate | Multivariable | Multivariable† | HR (95% CI) | value | HR (95% CI) | value | HR (95% CI) | value |
| Leucine | | | | | | | Leucine 109-174 μM (reference) | | | | | | | | 2.16 (1.30-3.59) | 0.003 | 2.03 (1.22-3.37) | 0.006 | 2.06 (1.22-3.47) | 0.007 | | 1.66 (1.10-2.51) | 0.015 | 1.52 (1.01-2.31) | 0.043 | 0.95 (0.60-1.50) | 0.828 | Age (years) | 1.02 (1.00-1.03) | 0.046 | | | | | APACHE II score | 1.12 (1.09-1.16) | <0.001 | 1.08 (1.06-1.11) | <0.001 | 1.09 (1.05-1.12) | <0.001 | SOFA score | 1.23 (1.17-1.28) | <0.001 | 1.14 (1.07-1.21) | <0.001 | 1.18 (1.11-1.24) | <0.001 | COPD | 0.27 (0.09-0.86) | 0.027 | | | | | C-reactive protein (log) | 2.21 (1.62-3.01) | <0.001 | 2.26 (1.65-3.10) | <0.001 | | | Cholesterol (mg/dL) | 0.99 (0.98-0.99) | <0.001 | 0.98 (0.98-0.99) | <0.001 | | | Albumin (g/dL) | 0.392 (0.29-0.53) | <0.001 | 0.41 (0.29-0.54) | <0.001 | | | Prealbumin (mg/dL) | 0.92 (0.89-0.95) | <0.001 | 0.92 (0.89-0.95) | <0.001 | | | Transferrin (mg/dL) | 0.99 (0.98-0.99) | <0.001 | 0.98 (0.98-0.99) | <0.001 | | |
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APACHE: acute physiology and chronic health evaluation; CI: confidence interval; COPD: chronic obstructive pulmonary disease; HR: hazard ratio; SOFA: sequential organ failure assessment. , adjusting for age and COPD. †, adjusting for age, COPD, C-reactive protein, cholesterol, albumin, prealbumin, and transferrin. |