Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma

Table 1

Correlations between CCDC45 expression and the clinicopathological features of HCC patients.

Characteristics		CCDC45 expression		value
		Low	High
Age (years)
>50	50	25 (50.00%)	25 (50.00%)	1.000
≤50	40	20 (50.00%)	20 (50.00%)
Gender
Male	80	39 (48.75%)	41 (51.25%)	0.502
Female	10	6 (60.00%)	4 (40.00%)
AJCC stage
I	52	30 (57.69%)	22 (42.31%)	0.088
II-III	38	15 (39.47%)	23 (60.53%)
HBsAg
Negative	19	9 (47.37%)	10 (52.63%)	0.796
Positive	71	36 (50.70%)	35 (49.30%)
AFP (μg/L)
>400	33	15 (45.45%)	18 (54.55%)	0.512
400	57	30 (52.63%)	27 (47.37%)
Total bilirubin (μmol/L)
>20	15	8 (53.33%)	7 (46.67%)	0.777
≤20	75	37 (49.33%)	38 (50.67%)
ALT (U/L)
>45	31	16 (51.61%)	15 (48.39%)	0.824
45	59	29 (49.15%)	30 (50.85%)
GGT (U/L)
> 40	59	28 (47.46%)	31 (52.54%)	0.506
40	31	17 (54.84%)	14 (45.16%)
Edmondson-Steiner grade
I-II	53	32 (60.38%)	21 (39.62%)	0.018
III-IV	37	13 (35.14%)	24 (64.86%)
Tumor number
Single	79	41 (51.90%)	38 (48.10%)	0.522
Multiple	11	4 (36.36%)	7 (63.64%)
Tumor size (cm)
> 5	28	11 (39.29%)	17 (60.71%)	0.172
5	62	34 (53.84%)	28 (46.16%)