Coiled-Coil Domain-Containing Protein 45 Is a Potential Prognostic Biomarker and Is Associated with Immune Cell Enrichment of Hepatocellular Carcinoma

Table 2

Univariate and multivariate survival analyses of clinicopathological variables of HCC patients.

Characteristics	Overall survival
	Univariate analysis			Multivariate analysis
	HR	95% CI	value	HR	95% CI	value
CCDC45 expression	14.635	(4.424-48.412)	<0.001	11.413	(3.402-38.285)	<0.001
Low vs. high
Age (years)	1.318	(0.352-1.476)	0.371
≤50 vs. >50
Gender	0.536	(0.128-2.249)	0.394
Male vs. female
AJCC stage	2.469	(1.197-5.092)	0.014	1.655	(0.790-3.466)	0.182
I vs. II-III
HBsAg	0.692	(0.265-1.806)	0.452
Negative vs. positive
AFP (ng/ml)	1.182	(0.574-2.436)	0.650
≤ 400 vs. >400
Total bilirubin (μmol/L)	0.930	(0.357-2.424)	0.882
≤20 vs. >20
ALT (U/L)	0.867	(0.408-1.812)	0.711
≤ 45 vs. >45
GGT (U/L)	0.401	(0.164-0.977)	0.044	0.470	(0.184-1.203)	0.115
≤ 40 vs. >40
Edmondson-Steiner grade	4.985	(2.274-10.928)	< 0.001	3.335	(1.497-7.428)	0.003
I-II vs. III-IV
Tumor number	1.887	(0.771-4.621)	0.165
Single vs. multiple
Tumor size (cm)	2.103	(1.033-4.281)	0.041	1.183	(0.560-2.502)	0.660
≤ 5 vs. >5