Grey Matter Hypertrophy and Atrophy in Early-Blind Adolescents: A Surface-Based Morphometric Study
Table 1
The significant altered cortical morphometry regions in EBA when compared with the NSC group.
Cortical morphometrics
Brain regions
Max
VtxMax
Size (mm2)
MNIX
MNIY
MNIZ
CWP
NVtxs
CT of left hemisphere
Superior parietal lobule
-5.693
19424
65.24
-26.9
-52.6
62.4
0.0002
131
Cuneus
5.055
68981
64.45
-4.6
-70.3
13.7
0.0002
80
Pericalcarine
3.454
112523
44.64
-8.6
-92.5
7.4
0.01157
44
Lingual
3.635
56056
41.46
-16.7
-87.6
-8.3
0.01931
42
Pericalcarine
4.816
28560
38.47
-23.8
-68.9
7.6
0.03332
97
Superior temporal gyrus
4.332
84916
36.35
-60.4
-14.8
-3
0.04996
74
CT of right hemisphere
Lateral occipital gyrus
4.3
136992
50.41
13.2
-100.6
3.7
0.0042
68
Lingual
-4.572
148749
39.79
25.8
-46.8
-6.4
0.02761
69
CV of left hemisphere
Pericalcarine
-5.638
75563
137.23
-14.8
-81.3
7.4
0.0002
264
Pericalcarine
-3.068
29579
11.77
-13.3
-85.8
7.1
0.0014
21
Rostral middle frontal gyrus
-3.424
4470
11.23
-32
31.7
34.9
0.0016
15
CV of right hemisphere
Pericalcarine
-4.575
86494
11.35
15.1
-75
6.4
0.0026
18
Pericalcarine
-4.192
61382
8.49
7
-84.1
8.4
0.02997
11
SA of left hemisphere
Pericalcarine
-5.796
128114
155.1
-12.1
-77.7
3.7
0.0002
260
Pericalcarine
-5.497
158064
146.1
-21.1
-71.3
7.8
0.0002
291
Pericalcarine
-5.581
41148
70.84
-13.6
-90.8
3
0.0002
86
Pericalcarine
-6.195
39176
52.31
-6.1
-91.9
7.8
0.0002
55
Pericalcarine
-4.742
126455
41.71
-7.1
-85.4
11.1
0.0002
56
Lingual
-5.064
162439
21.18
-26.3
-65.3
2.4
0.0002
56
Cuneus
-5.263
158481
17.78
-4.9
-91.6
8.4
0.0002
19
Lingual
-4.92
17525
16.56
-4.1
-83.3
-0.8
0.0002
23
Cuneus
-3.621
135774
15.94
-3.7
-77.8
13
0.0002
23
Cuneus
-3.461
39164
11.3
-4.7
-88.4
17.8
0.0016
13
Cuneus
-4.573
68974
9.96
-7.1
-71.3
16
0.00519
14
Lingual
-3.504
114632
9.52
-7.7
-84
-5.2
0.00878
7
Lingual
-5.023
162465
8.44
-16.4
-64.3
0.4
0.02662
13
Lingual
-3.355
139407
7.99
-21.6
-62.4
-0.1
0.04528
14
SA of right hemisphere
Pericalcarine
-4.964
25443
99.08
12.4
-88
1.3
0.0002
141
Pericalcarine
-5.676
161917
90.23
6.7
-80.6
1.4
0.0002
112
Lingual
-5.595
132374
68.78
16.4
-69.2
3.7
0.0002
104
Pericalcarine
-6.278
86238
66.94
13.8
-85.9
8.1
0.0002
90
Pericalcarine
-4.442
27615
23.38
8.8
-84
8.9
0.0002
30
Pericalcarine
-5.256
135388
15.09
24.3
-66.1
7.6
0.0002
35
Pericalcarine
-5.472
43531
13.78
19
-70.7
10.2
0.0004
26
Lingual
-4.629
35860
12.7
5.3
-67.9
6.1
0.0006
23
Lingual
-4.082
22548
9.47
18.6
-80.2
-12.1
0.01355
8
Lingual
-3.719
90574
8.94
8.4
-77.4
-1.8
0.0199
8
Pericalcarine
-4.312
156632
8.9
13.6
-91.7
7.1
0.0203
15
Pericalcarine
-3.263
118284
8.65
16.1
-94.8
3.4
0.02642
10
Lingual
-3.418
95382
8.63
8.3
-61.5
1.3
0.02662
16
Abbreviations: EBA: early-blind adolescents; NSC: normal-sighted controls; CT: cortical thickness; CV: cortical volume; SA: surface area; MNIX, Y, Z:the MNI coordinate of peak vertex; VtsMax: number of peak vertex of the significant cluster; CWP: cluster-wise probability and the nominal value; NVtxs: number of vertices in cluster.
