Review Article
Prognostic Value of NOX4 Expression in Cancer Patients: A Systematic Review and Meta-analysis
Table 1
Basic information of the selected studies.
| | Study | Country | Cancer type | Sample size | Sex (male/female) | Mean or median age (years) | Study period | Follow-up (months) | Survival outcome | NOX4
detection method | NOX4 expression associated with poor prognosis | Cut-off value of
NOX4 expression | Survival analysis | NOS |
| | Chen et al. (2020) [5] | Taiwan | Esophageal squamous cell carcinoma | 121 | 116/5 | Mean55 (29-80) | 2001-2012 | NA | OS, DFS | IHC | High expression | ≥50% | MVA | 7 | | Degasper et al. (2019) [6] | Austria | Endometrial cancer | 239 | - | Median 69 (37-93) | 1989-2015 | NA | OS | RT-PCR | High expression | >76 percentile | MVA | 7 | | Eun et al. (2019) [11] | South Korea | Hepatocellular carcinoma | 134 | 103/31 | Mean58.1 | 1999-2014 | Mean 49.15 (OS), 34.92 (DFS) | OS, DFS | IHC | High expression
(Nuclear) | Staining scores with intensity and proportion (>3) | UVA | 7 | | You et al. (2018) [16] | China | Gastric cancer | 876 | NA | NA | NA | NA | OS | HPA and Oncomine data | High expression | >median expression | UVA | 6 | | Cho et al. (2018) [7] | South Korea | Colorectal cancer | 458 | 242/216 | NA | NA | NA | OS | TCGA data | High expression | >39.13 | UVA | 6 | | Chen et al. (2018) [8] | Taiwan | Tongue squamous cell carcinoma | 161 | 148/13 | Median 53 (26-86) | 2006-2015 | 62.8 (2.3-117.6) | OS, DFS | IHC | High expression | ≥50% | MVA | 8 | | Lin et al. (2017) [13] | China | Colorectal cancer | 82 | 47/35 | NA | 2009 | 1-77 | OS | IHC | High expression | Staining scores with intensity and proportion (≥4) | MVA | 8 | | Eun et al. (2017) [10] | South Korea | Hepatocellular carcinoma | 377 | 255/122 | NA | NA | NA | OS | TCGA data | Low expression | <43.96 | UVA | 6 | | Ha et al. (2016) [12] | South Korea | Hepatocellular carcinoma | 227 | 135/92 | Median 53 | 2000-2006 | 120.3 (14-151.4) | OS, RFS | IHC | Low expression | ≤50% | MVA | 8 |
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DFS, disease-free survival; HPA, Human Protein Atlas; IHC, immunohistochemistry; MVA, multivariate analysis; NA, not available; NOS, Newcastle-Ottawa Scale; NOX4, NADPH oxidase 4; OS, overall survival; RFS, recurrence-free survival; RT-PCR, reverse transcription-polymerase chain reaction; TCGA, The Cancer Genome Atlas; UVA, univariate analysis.
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