Prognostic Value of NOX4 Expression in Cancer Patients: A Systematic Review and Meta-analysis

Table 3

Subgroup analysis and meta-regression of the association between NOX4 expression and disease-free survival in cancer patients.

Subgroup					Heterogeneity		Meta-regression
	Number of studies	Number of patients	Pooled HR (95% CI)	p value	I^2 (%)	p value	p value
Cancer type							-
HCC	2	361	0.61 (0.21-1.76)	0.36	96.89	< 0.001
Others	2	282	1.87 (1.30-2.68)	< 0.001	0.00	0.77
Sample size							-
Less than 150	2	255	1.29 (0.76-2.20)	0.35	80.41	0.02
More than 150	2	388	0.82 (0.15-4.56)	0.82	96.05	< 0.001

CI, confidence interval; HCC, hepatocellular carcinoma; HR, hazard ratio; NOX4, NADPH oxidase 4.