Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study
Table 2
Allele and genotype frequencies of the +61 A>G EGF (rs4444903) and +142285 G>A EGFR (rs2227983) polymorphisms in study groups (), age- and sex-adjusted.
Diagnosis
Group 2
RE
RE vs. Group 2 ORadj (95% CI)
value
BE
BE vs. Group 2 ORadj (95% CI)
value
EAC
EAC vs. Group 2 ORadj (95% CI)
value
Group 1
Group 1 vs. Group 2 ORadj (95% CI)
value
EGF A/G (rs4444903)
GG
16.0%
13.7%
0.85 (0.42-1.71)
0.642
21.7%
1.37 (0.60-3.09)
0.452
16.7%
1.79 (0.51-6.30)
0.366
16.6%
1.01 (0.53-1.91)
0.981
AG
50.0%
46.0%
0.86 (0.52-1.43)
0.567
38.0%
0.60 (0.31-1.14)
0.116
50.0%
0.80 (0.33-1.96)
0.627
44.2%
0.80 (0.50-1.27)
0.337
AA
34.0%
40.4%
1.28 (0.76-2.15)
0.354
40.2%
1.39 (0.73-2.67)
0.317
33.3%
0.93 (0.37-2.36)
0.879
39.2%
1.27 (0.78-2.07)
0.334
Allele G
41.0%
36.6%
0.85 (0.59-1.22)
0.373
40.8%
0.94 (0.59-1.48)
0.779
41.7%
1.20 (0.63-2.27)
0.577
38.7%
0.89 (0.64-1.25)
0.503
Allele A
59.0%
63.4%
1.18 (0.82-1.70)
59.2%
1.07 (0.68-1.68)
58.3%
0.83 (0.44-1.58)
61.3%
1.12 (0.80-1.57)
EGFR A/G (rs2227983)
AA
3.8%
7.5%
1.84 (0.57-5.96)
0.312
13.0%
3.04 (0.84-10.97)
0.089
8.3%
1.40 (0.25-7.93)
0.706
9.3%
2.22 (0.73-6.73)
0.157
AG
41.5%
38.5%
0.88 (0.53-1.46)
0.619
34.8%
0.70 (0.36-1.34)
0.277
37.5%
0.80 (0.32-1.98)
0.625
37.2%
0.84 (0.52-1.35)
0.464
GG
54.7%
54.0%
1.00 (0.61-1.66)
0.993
52.2%
1.03 (0.55-1.95)
0.920
54.2%
1.14 (0.47-2.78)
0.776
53.5%
0.99 (0.62-1.59)
0.978
Allele A
24.5%
26.7%
1.08 (0.72-1.63)
0.703
30.4%
1.19 (0.72-1.97)
0.495
27.1%
0.97 (0.48-1.98)
0.944
27.9%
1.13 (0.77-1.65)
0.537
Allele G
75.5%
73.3%
0.92 (0.62-1.39)
69.6%
0.84 (0.51-1.39)
72.9%
1.03 (0.51-2.08)
72.1%
0.89 (0.61-1.30)
Adj: adjusted OR for age and sex; BE: Barrett’s esophagus; CI: confidence interval; EAC: esophageal adenocarcinoma; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; NERD: nonerosive reflux disease group; OR: odds ratio; RE: reflux esophagitis; Group 1: patients with diagnosis RE, BE, or EAC determined by a pathologist; Group 2: patients without macroscopical changes of the esophageal mucosa and with/without NERD (including healthy individuals).
