Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study

Table 3

Gene-gene interaction: +61 A>G EGF (rs4444903) and +142285 G>A EGFR (rs2227983) between study groups (), age- and sex-adjusted.

EGF-EGFR interaction	Group 2		Group 1		Group 1 vs. Group 2; ORadj (95% CI)	value
EGF-EGFR	38	35.8%	91	30.2%	1.00 (ref.)
AA-AA	3	2.8%	10	3.3%	1.44 (0.35-5.94)	0.614
AA-AG	7	6.6%	39	13.0%	2.43 (0.96-6.13)	0.060
AA-GG	26	24.5%	69	22.9%	1.17 (0.63-2.17)	0.625
AG-GG	25	23.6%	70	23.3%	1.25 (0.67-2.33)	0.489
GG-GG	7	6.6%	22	7.3%	1.41 (0.52-3.81)	0.497

Adj: adjusted OR for age and sex; CI: confidence interval; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; NERD: nonerosive reflux disease group; OR: odds ratio; reference genotypes EGF-EGFR (AG-AA, AG-AG, GG-AA, and GG-AG) according to Upadhyay et al. [27]; Group 1: patients with diagnosis RE, BE, or EAC determined by a pathologist; Group 2: patients without macroscopical changes of the esophageal mucosa and with/without NERD (including healthy individuals).