Research Article
Lack of Association between Epidermal Growth Factor or Its Receptor and Reflux Esophagitis, Barrett’s Esophagus, and Esophageal Adenocarcinoma: A Case-Control Study
Table 4
Gene-gene interaction: +61 A>G EGF (rs4444903) and +142285 G>A EGFR (rs2227983) between the NERD patients and individual subgroups with RE/BE/EAC (), age- and sex-adjusted.
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Adj: adjusted OR for age and sex; BE: Barrett’s esophagus; CI: confidence interval; EAC: esophageal adenocarcinoma; EGF: epidermal growth factor; EGFR: epidermal growth factor receptor; GERD: gastroesophageal reflux disease group; NERD: non-erosive reflux disease group; OR: odds ratio; RE: reflux esophagitis; reference genotypes EGF-EGFR (AG-AA; AG-AG; GG-AA; GG-AG) according to Upadhyay et al. [27]; Group 2: patients without macroscopical changes of the esophageal mucosa and with/without NERD (including healthy individuals). |