Mining the Prognostic Role of DNA Methylation Heterogeneity in Lung Adenocarcinoma

<div>Landscape of LUAD prognosis-associated methylation sites. (a) The distribution of differentially methylated sites on chromosomes. (b) The 7336 methylation sites in 7 methylation clusters based on consensus clustering (<span class="nowrap"><svg height="9.49473pt" id="M30" style="vertical-align:-0.2063999pt" version="1.1" viewbox="-0.0498162 -9.28833 27.8499 9.49473" width="27.8499pt" xmlns="http://www.w3.org/2000/svg" xmlns:xlink="http://www.w3.org/1999/xlink"><g transform="matrix(.013,0,0,-0.013,0,0)"><path d="M480 416C480 431 465 448 438 448C388 448 312 383 252 330C217 299 188 273 155 237H153L257 680C262 700 263 712 253 712C240 712 183 684 97 674L92 648L126 647C166 646 172 645 163 606L23 -6L29 -12C51 -5 77 2 107 8C115 62 130 128 142 180C153 193 179 220 204 241C231 170 259 106 288 54C317 0 336 -12 358 -12C381 -12 423 2 477 80L460 100C434 74 408 54 398 54C385 54 374 65 351 107C326 154 282 241 263 299C296 332 351 377 403 377C424 377 436 372 445 368C449 366 456 368 462 375C472 386 480 402 480 416Z"></path></g><g transform="matrix(.013,0,0,-0.013,10.171,0)"><path d="M535 323V373H52V323H535ZM535 138V188H52V138H535Z"></path></g><g transform="matrix(.013,0,0,-0.013,21.434,0)"><path d="M447 623H65C61 580 56 530 47 475H76C100 541 106 550 172 550H388C308 376 196 170 91 -1L98 -12L172 -2C268 204 360 408 455 611L447 623Z"></path></g></svg>).</span> (c) Heatmap of the DNA methylation level incorporating DNA methylation subtypes, clinicopathological stage, and TNM stage. (d) The average number of methylation sites per cluster.</div>

Disease Markers

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Figure 1

Figure 1: Mining the Prognostic Role of DNA Methylation Heterogeneity in Lung Adenocarcinoma 