Actin-Binding LIM 1 (ABLIM1) Inhibits Glioblastoma Progression and Serves as a Novel Prognostic Biomarker

Figure 1

The ABLIM1 mRNA and protein expression in GBM. (a) The ABLIM1 mRNA level in glioma tissues with different WHO grades from the TCGA database was compared, indicating the lowest level in WHO grade IV glioma, namely the glioblastoma (GBM). The y-axis was plotted according to the transcripts per million (TPM) and converted to log₂ (TPM+1). (b) The ABLIM1 mRNA level in glioma tissues with different histological types from the TCGA database was compared, showing the lowest level in glioblastoma compared with other histological types. (c) We conducted a Kaplan-Meier survival analysis to compare the survival difference of glioma patients with low or high ABLIM1 mRNA levels using the data from the TCGA database. (d) The ABLIM1 mRNA level was compared between GBM and normal brain tissues using TCGA and GTEx databases (). Each red dot indicates a specific mRNA level in a GBM sample, while each green dot indicates normal brain tissue. (e) Representative low ABLIM1 protein expression in GBM as reflected using IHC, demonstrating almost negative expression in specific GBM samples. (f) Representative high ABLIM1 protein expression in GBM tissues using IHC, exhibiting a positive expression in the cytoplasm. , ; ns: no significance. Magnification: 400x.

(a)

(b)

(c)

(d)

(e)

(f)