Value of Central Venous Pressure Monitoring in the Patients with Sepsis-Associated Acute Kidney Injury
Table 2
Comparison of the effects of different CVP administration times on outcomes in propensity score-matched cohorts ().
Variables
≤3 h
4~6 h
7~12 h
13~24 h
value
CVP (mmHg, mean (SD))
17.3 (7.4)
14.1 (7.4)a
12.8 (6.7)a
19.0 (7.5)bc
<0.001
MAP (mmHg, mean (SD))
107.3 (32.9)
107.0 (34.7)
110.3 (38.4)
112.1 (37.9)
0.259
CI (L/min/m2, mean (SD))
3.4 (1.0)
2.7 (0.7)
3.0 (0.8)
3.1 (1.6)
0.181
Lac (mmol/L, mean (SD))
3.9 (3.5)
3.7 (2.8)
4.1 (3.2)
3.9 (2.6)
0.161
Fluid load (mL/kg, mean (SD))
4.5 (1.7)
4.4 (1.5)
4.7 (1.9)
4.8 (1.4)
0.095
MPP (mmHg, mean (SD))
90.0 (33.2)
92.9 (36.0)
97.5 (38.5)a
93.0 (37.5)
0.002
Primary outcome
28-day mortality, (%)
96 (21.4)
53 (22.9)
41 (22.4)
22 (23.7)
0.947
Secondary outcomes
In-hospital mortality, (%)
99 (22.0)
53 (22.9)
42 (23.0)
24 (25.8)
0.956
Length of ICU stay (day, mean (SD))
6.2 (8.6)
7.1 (8.0)a
7.1 (6.8)
6.9 (6.2)
0.021
Length of hospital stay (day, mean (SD))
10.9 (8.0)
12.2 (10.2)
11.3 (12.3)
12.8 (11.7)abc
<0.001
CVP level measure in the first 24 hours of admission to ICU. a vs. CVP measurement within 3 hours; b vs. CVP measurement from 4 to 6 hours; c vs. CVP measurement from 7 to 12 hours; a two-tailed value of <0.05 was considered statistically significant. CVP = central venous pressure; MAP = mean arterial pressure; CI = cardiac index; Lac = lactic acid; MPP = the mean perfusion pressure; ICU = intensive care unit.
