Identification of Significant Genes and Pathways for the Chronic and Subacute Cutaneous Lupus Erythematosus via Bioinformatics Analysis

Table 1

Gene ontology and KEGG analysis of DEGs in CCLE.

Ontology	ID	Description	GeneRatio	BgRatio	value	Adjusted	value
BP	GO:0009615	Response to virus	50/261	326/18670
BP	GO:0051607	Defense response to virus	44/261	238/18670
BP	GO:0043900	Regulation of multiorganism process	40/261	405/18670
BP	GO:0048525	Negative regulation of viral process	23/261	99/18670
BP	GO:0051249	Regulation of lymphocyte activation	40/261	485/18670
CC	GO:0009897	External side of plasma membrane	31/270	393/19717
CC	GO:0001533	Cornified envelope	7/270	65/19717		0.004	0.004
CC	GO:0030667	Secretory granule membrane	12/270	298/19717		0.082	0.077
MF	GO:0042379	Chemokine receptor binding	10/257	66/17697
MF	GO:0005126	Cytokine receptor binding	19/257	286/17697
MF	GO:0042287	MHC protein binding	8/257	40/17697
MF	GO:0005125	Cytokine activity	16/257	220/17697
MF	GO:0048020	CCR chemokine receptor binding	8/257	43/17697
KEGG	hsa04060	Cytokine-cytokine receptor interaction	28/143	295/8076
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	15/143	100/8076
KEGG	hsa05340	Primary immunodeficiency	10/143	38/8076
KEGG	hsa04621	NOD-like receptor signaling pathway	18/143	181/8076
KEGG	hsa04640	Hematopoietic cell lineage	12/143	99/8076