Identification of Significant Genes and Pathways for the Chronic and Subacute Cutaneous Lupus Erythematosus via Bioinformatics Analysis

Table 2

Gene ontology and KEGG analysis of DEGs in SCLE.

Ontology	ID	Description	GeneRatio	BgRatio	value	Adjusted	value
BP	GO:0009615	Response to virus	25/154	326/18670
BP	GO:0051607	Defense response to virus	22/154	238/18670
BP	GO:0034341	Response to interferon-gamma	18/154	199/18670
BP	GO:0071346	Cellular response to interferon-gamma	17/154	180/18670
BP	GO:0060337	Type I interferon signaling pathway	12/154	95/18670
MF	GO:0042288	MHC class I protein binding	4/153	20/17697		0.009	0.008
MF	GO:0008009	Chemokine activity	5/153	49/17697		0.012	0.011
MF	GO:0042379	Chemokine receptor binding	5/153	66/17697		0.033	0.030
MF	GO:0042287	MHC protein binding	4/153	40/17697		0.036	0.033
KEGG	hsa04060	Cytokine-cytokine receptor interaction	11/84	295/8076		0.023	0.022
KEGG	hsa05164	Influenza A	8/84	171/8076		0.023	0.022
KEGG	hsa04623	Cytosolic DNA-sensing pathway	5/84	63/8076		0.023	0.022
KEGG	hsa04621	NOD-like receptor signaling pathway	8/84	181/8076		0.023	0.022
KEGG	hsa04061	Viral protein interaction with cytokine and cytokine receptor	6/84	100/8076		0.023	0.022