hsa_circ_0139402 Promotes Bladder Cancer Progression by Regulating hsa-miR-326/PAX8 Signaling

Figure 2

hsa_circ_0139402 regulates BC cells’ proliferation, migration, and invasion. (a) sh-hsa_circ_0139402 could regulate the expression of hsa_circ_0139402 in UMUC3 and 5637 cells; (b) MMT assay showed that sh-hsa_circ_0139402 could regulate cell proliferation in UMUC3 and 5637 cells; (c–f) wound healing and transwell assays showed that hsa_circ_0139402 knockdown could regulate migration and invasion in UMUC3 and 5637 cells; (g) hsa_circ_0139402 knockdown affected cell cycle in 5637 cells; (h) BALB/c nude mice injected with 5637 cells cotransfected with sh-hsa_circ_0139402 had smaller volume. Data were represented as . compared with negative control.

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