Aldolase A Promotes Colorectal Cancer Progression through Targeting COPS6 and Regulating MAPK Signaling Pathway

Figure 3

ALDOA facilitated CRC growth and metastasis in vivo. (a) Morphologic characteristics of CRC xenograft tumors on the surface of female nude mice. (b) The volume of subcutaneous tumors in mice was measured every three days. . (c) An intuitive morphology of tumors collected after mice was sacrificed. (d, e) Tumor volumes and weights at 30 day were measured in each group. (f) The nude mice were weighed every three days, but no significant difference was observed. (g) Representative images of HE and ki-67 staining in CRC xenograft tumors from sh-Ctrl and sh-ALDOA nude mice. (h, k) Knockdown ALDOA inhibited lung metastasis in nude mice. (i, l) The number of lung surface metastasis lesions was counted. (j, m) No significant difference was observed between CRC metastasis models. , , and .

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