Research Article
Development and Interpretation of a Clinicopathological-Based Model for the Identification of Microsatellite Instability in Colorectal Cancer
Table 1
Clinical characteristics of the patients with colorectal cancer.
| | Level | | Overall | dMMR | PMMR | value | | 2279 | 177 | 2102 |
| | Gender (%) | Male | 1369 (60.1) | 107 (60.5) | 1262 (60.0) | 0.978 | | Female | 910 (39.9) | 70 (39.5) | 840 (40.0) | | | Age (%) | <53 | 833 (36.6) | 89 (50.3) | 744 (35.4) | <0.001 | | ≥53 | 1446 (63.4) | 88 (49.7) | 1358 (64.6) | | | Primary location (%) | Colon | 1082 (47.5) | 159 (89.8) | 923 (43.9) | <0.001 | | Rectum | 1197 (52.5) | 18 (10.2) | 1179 (56.1) | | | Tumor diameters (cm (%)) | <4.6 | 1420 (62.3) | 52 (29.4) | 1368 (65.1) | <0.001 | | ≥4.6 | 859 (37.7) | 125 (70.6) | 734 (34.9) | | | Pathological type (%) | Nonadenocarcinoma | 576 (25.3) | 61 (34.5) | 515 (24.5) | 0.01 | | Adenocarcinoma | 1703 (74.7) | 116 (65.5) | 1587 (75.5) | | | Histology (%) | Moderate | 1978 (86.7) | 137 (77.4) | 1839 (87.5) | <0.001 | | Poor | 303 (13.3) | 40 (22.6) | 263 (12.5) | | | No. of sampled LNs (m (%)) | <23 | 1735 (76.1) | 85 (48.0) | 1650 (78.5) | <0.001 | | ≥23 | 544 (23.9) | 92 (52.0) | 452 (21.5) | | | No. of positive LNs (n) (mean (SD)) | | 2.02 (3.85) | 0.89 (2.90) | 2.12 (3.90) | <0.001 | | T-stage (%) | I/II | 405 (17.8) | 20 (11.3) | 385 (18.3) | 0.025 | | III/IV | 1874 (82.2) | 157 (88.7) | 1717 (81.7) | | | N-stage (%) | N0 | 1249 (54.8) | 134 (75.7) | 1115 (53.0) | <0.001 | | N2 | 430 (18.9) | 11 (6.2) | 419 (19.9) | | | N1 | 600 (26.3) | 32 (18.1) | 568 (27.0) | | | M-stage (%) | 0.00 | 2237 (98.2) | 174 (98.3) | 2063 (98.1) | 1.00 | | 1.00 | 42 (1.8) | 3 (1.7) | 39 (1.9) | | | TNM (%) | 1.00 | 319 (14.0) | 18 (10.2) | 301 (14.3) | <0.001 | | 2.00 | 913 (40.1) | 115 (65.0) | 798 (38.0) | | | 3.00 | 1005 (44.1) | 41 (23.2) | 964 (45.9) | | | 4.00 | 42 (1.8) | 3 (1.7) | 39 (1.9) | | | Perineural invasion (%) | No | 1549 (68.0) | 160 (90.4) | 1389 (66.1) | <0.001 | | Yes | 730 (32.0) | 17 (9.6) | 713 (33.9) | | | Vascular cancer embolus (%) | No | 1734 (76.1) | 146 (82.5) | 1588 (75.5) | 0.047 | | CA72-4(%) | Normal | 1891 (83.0) | 120 (67.8) | 1771 (84.3) | <0.001 | | High | 388 (17.0) | 57 (32.2) | 331 (15.7) | | | CA199 (%) | Normal | 1855 (81.4) | 144 (81.4) | 1711 (81.4) | 1.000 | | High | 424 (18.6) | 33 (18.6) | 391 (18.6) | | | AFP | Low | 298 (13.1) | 34 (19.2) | 264 (12.6) | 0.036 | | Normal | 1957 (85.9) | 142 (80.2) | 1815 (86.3) | | | High | 24 (1.1) | 1 (0.6) | 23 (1.1) | | | SCC (%) | Normal | 2174 (95.4) | 168 (94.9) | 2006 (95.4) | 0.897 | | High | 105 (4.6) | 9 (5.1) | 96 (4.6) | | | NSE (%) | Normal | 1513 (66.4) | 122 (68.9) | 1391 (66.2) | 0.508 | | High | 766 (33.6) | 55 (31.1) | 711 (33.8) | | | CA125 (%) | Normal | 2060 (90.4) | 157 (88.7) | 1903 (90.5) | 0.508 | | High | 219 (9.6) | 20 (11.3) | 199 (9.5) | | | CA15-3 (%) | Normal | 872 (38.3) | 83 (46.9) | 789 (37.5) | 0.017 | | High | 1407 (61.7) | 94 (53.1) | 1313 (62.5) | | | FERR (%) | Low | 1134 (49.8) | 123 (69.5) | 1011 (48.1) | <0.001 | | Normal | 1018 (44.7) | 49 (27.7) | 969 (46.1) | | | High | 127 (5.6) | 5 (2.8) | 122 (5.8) | | | CYFRA21-1 (%) | Normal | 1706 (74.9) | 132 (74.6) | 1574 (74.9) | 1.000 | | High | 573 (25.1) | 45 (25.4) | 528 (25.1) | |
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