Development and Interpretation of a Clinicopathological-Based Model for the Identification of Microsatellite Instability in Colorectal Cancer

Table 2

Risk factors for deficient MMR in colorectal cancer. Five predictive models based on simplified clinicopathological features and serum tumor biomarkers.

Characteristic	OR^1	95% CI^1	value
Age			<0.001
<53	—	—
≥53	2.93	1.54, 5.72
Primary location			<0.001
Colon	—	—
Rectum	10.5	4.95, 23.9
Tumor diameters (cm)			<0.001
<4.6	—	—
≥4.6	0.24	0.12, 0.46
Pathological type			0.23
Nonadenocarcinoma	—	—
Adenocarcinoma	1.53	0.76, 3.10
Histology			0.21
Well/moderate	—	—
Poor	0.59	0.25, 1.35
No. of sampled LNs()			0.009
<23	—	—
≥23	0.42	0.21, 0.80
N-stage			0.76
N0	—	—
N1	2.67	0.02, 515
N2	5.58	0.02, 1683
Perineural invasion			0.028
No	—	—
Yes	2.87	1.12, 7.85
NSE			0.018
Normal	—	—
High	2.20	1.15, 4.33
No. of positive LNs()	1.14	0.87, 1.73	0.47
CA72.4			0.23
Normal	—	—
High	0.65	0.31, 1.32
TNM			0.71
1	—	—
2	1.86	0.65,5.34
3	1.30	0.01, 195
4	1.24	0.02, 90.2

¹OR: odds ratio, CI: confidence interval.