Disease Markers

Promising Biomarkers for Risk Stratification and Prognostication of Heart Failure in Diabetics


Publishing date
01 Jul 2021
Status
Closed
Submission deadline
26 Feb 2021

1Zaporizhzhia State Medical University, Zaporizhia, Ukraine

2Paracelsus Medical University, Salzburg, Austria

This issue is now closed for submissions.
More articles will be published in the near future.

Promising Biomarkers for Risk Stratification and Prognostication of Heart Failure in Diabetics

This issue is now closed for submissions.
More articles will be published in the near future.

Description

Biomarkers are surrogate indicators of pathophysiological states of several conditions including heart failure (HF) having various diagnostic potencies and predictive values. Current clinical guidelines reported by American Heart Association and European Cardiology Society have proposed to use advanced medical care for HF patients with diabetes using biomarkers, to diagnose HF and stratify patients at higher risk of poor prognosis, while these biomarkers have demonstrated several limitations among diabetics. Conventional biomarkers of biomechanical stress (natriuretic peptides) had been implemented as a diagnostic and predictive tool for predominantly HF with reduced ejection fraction (HFrEF), but have exhibited controversial results regarding prognostication of clinical outcomes directly related to HF in diabetics treated with sodium-glucose cotransporter (SGLT)-2 inhibitors and glucagon-like peptide (GLP)-1 agonists. The inflammatory biomarkers and biomarkers of fibrosis are not commonly used in routine clinical practice and require evaluation in diabetics with HFrEF and HF with preserved ejection fraction.

The role of the biomarkers, which reflect an activity of co-existing oxidative stress, fibrosis, myocardial hypertrophy and inflammation, are controversial. Non-coding RNAs including small non-coding RNAs (microRNAs, circular RNAs, and long non-coding RNAs), which are regulators insulin resistance, cardiomyocytes apoptosis, and microvascular inflammatory, myocardial hypertrophy, have been critically evaluating especially around their protective effect on cardiac function. Novel biomarkers (adipocytokines, matrix metalloproteinases and their tissue inhibitors, vascular endothelial growth factor, collagen degradation products) are deeply discussed in the context of risk stratification on diabetics with various HF phenotypes. Multiple biomarker predictive strategies will be considered as a promising tool to improve point-of-care amid diabetics with HF during treatment with new antidiabetic drugs.

The goal of this Special Issue is to unveil new perspectives for screening, diagnosis, stratification, and prediction of heart failure in diabetics using biomarkers. Original research and reviews are welcome to clearly elucidate the importance of different biomarkers in heart failure among diabetics.

Potential topics include but are not limited to the following:

  • Current biomarker-based risk assessment in diabetics with heart failure
  • Natriuretic peptides in heart failure patients with known diabetes mellitus
  • Inflammatory biomarkers in diabetics with various phenotypes of heart failure
  • Functions and underlying mechanisms of non-coding RNAs in diabetes cardiomyopathy
  • Adipocytokines in diabetics with heart failure
  • Genes predictive score in heart failure
  • Promising biomarkers for ameliorating prognostication in diabetes mellitus cardiomyopathy
  • Future in biomarker-based predictive models in heart failure patients treated with antidiabetic drugs

Articles

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  • - Volume 2021
  • - Article ID 6689056
  • - Research Article

HDL-C/apoA-I Ratio Is Associated with the Severity of Coronary Artery Stenosis in Diabetic Patients with Acute Coronary Syndrome

Lizhe Sun | Manyun Guo | ... | Zuyi Yuan
  • Special Issue
  • - Volume 2021
  • - Article ID 6690095
  • - Research Article

Exploring the Relationship of Bone Turnover Markers and Bone Mineral Density in Community-Dwelling Postmenopausal Women

Xu Wei | Yili Zhang | ... | Liguo Zhu
  • Special Issue
  • - Volume 2021
  • - Article ID 6677823
  • - Research Article

The Value of a Seven-Autoantibody Panel Combined with the Mayo Model in the Differential Diagnosis of Pulmonary Nodules

Zhougui Ling | Jifei Chen | ... | Zhuojun Hu
  • Special Issue
  • - Volume 2021
  • - Article ID 6644631
  • - Review Article

Myokines and Heart Failure: Challenging Role in Adverse Cardiac Remodeling, Myopathy, and Clinical Outcomes

Alexander E. Berezin | Alexander A. Berezin | Michael Lichtenauer
  • Special Issue
  • - Volume 2020
  • - Article ID 6659166
  • - Research Article

Association between Cardiac Autonomic Neuropathy and Coronary Artery Lesions in Patients with Type 2 Diabetes

Lei Liu | Qiansheng Wu | ... | Qiang Zhou
  • Special Issue
  • - Volume 2020
  • - Article ID 8830471
  • - Review Article

The Role of Circulating RBP4 in the Type 2 Diabetes Patients with Kidney Diseases: A Systematic Review and Meta-Analysis

Li Zhang | Yan-Li Cheng | ... | Zhong-Gao Xu
  • Special Issue
  • - Volume 2020
  • - Article ID 8850816
  • - Research Article

Evaluation of Altered Glutamatergic Activity in a Piglet Model of Hypoxic-Ischemic Brain Damage Using 1H-MRS

Yuxue Dang | Xiaoming Wang
Disease Markers
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