Disease Markers

Developmental Gene Markers in Tumor Pathogenesis and Progression


Publishing date
01 May 2019
Status
Published
Submission deadline
28 Dec 2018

Lead Editor

1INT Fondazione Pascale, Naples, Italy

2National Research Council, Sassari, Italy

2INT Fondazione Pascale, Naples, Italy


Developmental Gene Markers in Tumor Pathogenesis and Progression

Description

At the end of the 1970s, Ibsen et al. hypothesized that the deregulation of genes involved in embryonic development could play a fundamental role in the pathogenic mechanisms of tumor diseases.

In particular the aberrant activity of the genes that regulate cell differentiation and morphogenesis during embryonic development appears to be associated with specific oncogenic processes, from the control of cell growth, proliferation, and apoptosis, to cell invasion and epithelial mesenchymal transition.

In this context, one of the most striking examples is represented by the homeobox gene family, a superfamily of transcription factors, mostly involved in the control of the identity of various regions along the body axis, from the branchial area to the tail. In particular, the deregulation of Class I Homeobox genes (HOX genes) is described as strongly associated with neoplastic transformation and disease progression in several human cancers.

Additionally, in recent years several noncoding RNA (ncRNA) sequences have been identified in HOX loci, including long noncoding RNAs (lncRNA) and microRNAs (miRNA). The high level of conservation between these adjacent genes during evolution could suggest their critical role in the regulation of HOX gene expression in normal and pathological conditions.

In this special issue we aim to provide readers with an overview of the latest studies concerning the regulation and deregulation of developmental genes and noncoding RNAs involved in tumor pathogenesis and progression.

Potential topics include but are not limited to the following:

  • Homeobox genes and HOX genes as tumor markers
  • Notch signaling pathway in tumor pathogenesis and progression
  • MiRNAs in developmental genes regulation and cancer
  • LncRNAs in developmental genes regulation and cancer

Articles

  • Special Issue
  • - Volume 2019
  • - Article ID 5462562
  • - Editorial

Developmental Gene Markers in Tumor Pathogenesis and Progression

Monica Cantile | Giuseppe Palmieri | Gerardo Botti
  • Special Issue
  • - Volume 2019
  • - Article ID 7129214
  • - Research Article

TFAP4 Promotes Hepatocellular Carcinoma Invasion and Metastasis via Activating the PI3K/AKT Signaling Pathway

Tao Huang | Qi-Feng Chen | ... | Wei-Jun Fan
  • Special Issue
  • - Volume 2019
  • - Article ID 3857853
  • - Research Article

An Oncogenic Role for Four-Jointed Box 1 (FJX1) in Nasopharyngeal Carcinoma

San Jiun Chai | Muhammad Mamduh Ahmad Zabidi | ... | Sok Ching Cheong
  • Special Issue
  • - Volume 2019
  • - Article ID 6328503
  • - Research Article

DNA Methylation Profiles and Their Diagnostic Utility in BC

Ming Shan | Lei Zhang | ... | Guoqiang Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 3768708
  • - Research Article

Loss of SDC1 Expression Is Associated with Poor Prognosis of Colorectal Cancer Patients in Northern China

Kaizhi Li | Lei Li | ... | Wei Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 3949343
  • - Research Article

Association between AXIN1 Gene Polymorphisms and Bladder Cancer in Chinese Han Population

Qin Li | Peng Zhang | ... | Lin Zhang
  • Special Issue
  • - Volume 2019
  • - Article ID 8282414
  • - Research Article

High SALM3 Expression in Tumor Cells and Fibroblasts Is Correlated with Poor Prognosis in Gastric Cancer Patients

Ying Liu | Xiaoli Chen | ... | Han Wu
  • Special Issue
  • - Volume 2019
  • - Article ID 5231269
  • - Research Article

High Expression of LTBP2 Contributes to Poor Prognosis in Colorectal Cancer Patients and Correlates with the Mesenchymal Colorectal Cancer Subtype

Ying Huang | Guihua Wang | ... | Xudong Wang
  • Special Issue
  • - Volume 2019
  • - Article ID 2673543
  • - Review Article

Roles of Methylated DNA Biomarkers in Patients with Colorectal Cancer

Zhiyao Ma | Marissa Williams | ... | Wai K. Leung
Disease Markers
 Journal metrics
Acceptance rate34%
Submission to final decision86 days
Acceptance to publication43 days
CiteScore2.640
Impact Factor2.761
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