An Experimental In Vivo Model to Characterize “Heavy Legs” Symptom in Topical Formulations

Table 1

Skin microcirculation blood flow obtained during single (basal) and dynamical (Provocation, Postprovocation) measurements at each evaluation day (^∗𝑃<.05; NS: Nonsignificant: Comparison against D0).

BPU	Treated leg			Nontreated (control) leg
	D0	D14	D28	D0	D14	D28
Basal	40.1+36.8	55.4+31.8^NS	95.65+55.8^NS	31.6+25.7	87.1+55.8^∗	148.9+126.7^∗
Provocation	64.9+48.5	66.5+37.3^NS	111.4+56.7^NS	58.3+42.3	107.4+62.3^∗	154.3+99.5^∗
Post provocation	26.7+29.6	36.3+20.1^NS	105.7+75.9^∗	20.5+16.9	60.7+37.0^∗	131.6+95.6^∗