Desmosomal Molecules In and Out of Adhering Junctions: Normal and Diseased States of Epidermal, Cardiac and Mesenchymally Derived Cells

Figure 1

High-magnification electron micrograph of two cross sectioned desmosomal structures connecting stratum spinosum cells of human fetal (20 wk) foot-sole epidermis. Brackets and label “P”: cytoplasmic dense plaque; black arrows: midline structure; white arrows: trilaminar “unit membrane” structure of the plasma membrane; arrowheads (top and bottom): secondary dense layer of the plaque; IF: intermediate-sized filaments (for further details see [7]); PM: plasma membrane. Bar: 0.1 𝜇m.