A New Perspective on Intercalated Disc Organization: Implications for Heart Disease
Model for cadherin-based area composita in the heart. T-catenin recruits desmosomal protein, plakophilin- (PKP-) 2 to hybrid adhering junction (left drawing), thereby forming, together with desmosome (right drawing), an area composita, which is an enforced, mixed-type junctional structure attached to both the actin cytoskeleton and the intermediate filament (PG: plakoglobin; DP: desmoplakin).
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