The Influence of Pregnancy on the Recurrence of Cutaneous Malignant Melanoma in Women

Table 2

Critical appraisal.

Study

Study design

Relevance

Blinding

Missing Data

Internal validity

Results

Domain

Determinant

Outcome

Determinant

Outcome

Follow-up (months)

Drop-out (%)

Loss-to-follow-up (%)

Selectionbias

Informationbias

External Validity

Standardisation

Level of Evidence [8]

Effect measures

Precision measures

Bork et al. [6]

Retrospective

Women in the childbearing years with stage I malignant melanoma.

Pregnancy after primary therapy.

Recurrence & Disease-free survival.

n.a.

n.a.

n.a.

?

?

n.a.

n.a.

−

−

3

None

None

Reintgen et al. [9]

Retrospective case/control

Women in the childbearing years treated for stage I primary cutaneous melanoma.

Pregnancy within 5 years of diagnosis.

Disease-free interval (10 years).

n.a.

n.a.

n.a.

None

None

n.a.

n.a.

+

±

2B

𝜒^2

P

Shaw et al. [5]

Retrospective

Women with malignant melanoma.

Pregnancy after diagnosis.

Local recurrence.

n.a.

n.a.

n.a.

?

?

n.a.

n.a.

−

?

3

None

None

MacKie et al. [10]

Retrospective cohort

Women in the reproductive years treated for stage I primary melanoma.

First pregnancy after diagnosis.

Disease-free survival (20 years).

n.a.

n.a.

n.a.

None

None

n.a.

n.a.

+

±

2B

RR

p&CI

+: Good, ±: Moderate, −: Poor, ?: Unknown, n.a.: Not Applicable, RR: Relative risk, CI: Confidence Interval, P: P-value.